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Objectives: The purposes of this research were: 1. to assess the effectiveness of PRP injections into facial skin and to identify which of the studied blood parameters can affect the effectiveness of the procedure; 2. to study the safety of the PRP injections into the facial skin and assess its effect on immune system according to the routine laboratory tests. 3. to propose an examination algorithm before the procedure of PRP injections into the facial skin, in order to ensure safety and reduce side effects from the procedure. Introduction: Autologous platelet-rich plasma (PRP) is particularly popular in various fields of medicine (including aesthetic dermatology and cosmetology) because it releases numerous chemokines, cytokines, and growth factors that stimulate angiogenesis, extracellular matrix remodelling, cell differentiation and proliferation. All the molecular mechanisms of PRP’s action that promote tissue regeneration as well as systemic reactions to the PRP administration have not been studied sufficiently. There are few studies on the safety of PRP’s use, most of them was focused on studying local immune responses. Materials / method: The research involved 50 women aged 20 to 52 years who received intradermal PRP injections into facial skin. Injections were administered using own proprietary method. Complete blood count, rheumatoid factor, lupus anticoagulant, D-dimer, estradiol, and insulin in the blood serum were measured. A general examination, assessment of the skin’s condition using a facial skin analyzer, assessment of midface volume changes using the MVDS scale, assessment of aesthetic improvement by the doctor and the patient (GAIS) were conducted. Results: According to the GAIS the majority noted some improvement in the skin condition; however, according to the skin analyzer data, there were no significant changes. A total of 56% of the patients displayed improvement in the midface volume, and this was observed in patients with a lower blood platelet count and a higher level of estradiol. No undesirable local or systemic reactions after the procedure. We recommend an examination algorithm before the procedure of PRP injections into the facial skin, which includes routine laboratory tests and a thorough history taking. Conclusion: PRP injections are a minimally invasive method compared to, for example, plastic surgery, and the advantages of using PRP are its availability, low cost, ease of use, and relative safety for many patients. An algorithm for laboratory examination of patients before the PRP injections into the facial skin is needed for admission to the procedure in order to minimize the possible side effects and to predict positive effects from the procedure. The safety research should be continued, taking into account the multiplicity of the procedure and its combination with other cosmetic effects.