Абстракт

Objectives: To introduce particulated human acellular dermal matrix (hADM) as a novel extracellular matrix (ECM)-based regenerative biomaterial and to demonstrate its expanding clinical applications in both aesthetic and surgical fields. Participants will understand the biologic mechanisms of hADM, recognize how it differs from hyaluronic acid fillers and synthetic biostimulators, and learn its practical indications for facial rejuvenation, volumization, and surgical tissue augmentation. The session aims to provide a regenerative treatment concept that combines structural support with physiologic tissue r Introduction: Facial rejuvenation has evolved from simple volume replacement toward biologic tissue regeneration. Hyaluronic acid fillers primarily act as space-occupying gels that provide immediate volumization, while synthetic biostimulators such as PLLA, PDLLA, CaHA, and PCL stimulate collagen production through inflammation-mediated foreign body reactions. Although effective, their outcomes depend on individual inflammatory responses and may be associated with prolonged inflammation, nodules, or inconsistent results. Particulated human acellular dermal matrix (hADM) preserves native extracellular matrix Materials / method: This presentation reviews the biologic rationale and clinical applications of particulated hADM based on current scientific evidence and the author's clinical experience. The regenerative mechanisms of ECM scaffolds are compared with those of conventional HA fillers and synthetic collagen stimulators. Representative clinical cases are presented, including full-face skin rejuvenation, under-eye hollow correction, pretarsal (aegyo-sal) augmentation, neck wrinkle treatment, biologic volumization, and adjunctive use in lower blepharoplasty. The advantages, limitations, injection concepts, and pote Results: Particulated hADM functions as an ECM scaffold that promotes physiologic tissue regeneration rather than relying on inflammation-mediated collagen stimulation. Clinically, it provides simultaneous improvement in tissue quality and structural support while maintaining a natural texture and contour. Compared with conventional fillers, it demonstrates a low risk of Tyndall effect, reduced migration and shape distortion, less overcorrection and edema, and a decreased likelihood of prolonged inflammatory complications. In surgical applications, hADM can improve soft tissue support and contour refin Conclusion: Particulated hADM bridges the gap between conventional fillers and synthetic biostimulators by combining structural augmentation with biologic regeneration. As an ECM-derived biomaterial, it promotes physiologic tissue remodeling while minimizing dependence on foreign body reactions, allowing more predictable and natural clinical outcomes. Its expanding indications across aesthetic injections and reconstructive surgery suggest that hADM may become a next-generation regenerative platform capable of improving both volume and tissue quality, offering new therapeutic possibilities in modern facial