Абстракт

Objectives: The objective of this study is to evaluate whether decreased serum testosterone levels in men are correlated with impaired skin-barrier function, as assessed by transepidermal water loss Introduction: Testosterone is known to influence several aspects of male skin physiology, including lipid production and barrier integrity. As men age, testosterone levels naturally decline, often accompanied by noticeable skin dryness. This study explores whether low serum testosterone is associated with measurable impairment in skin barrier function, assessed through transepidermal water loss (TEWL). Materials / method: This study was an observational analytic study with cross-sectional design to determine the relationship between total testosterone and TEWL in men with low testosterone level. This research was conducted in Outpatient Unit Andrology of dr. Soetomo. 16 samples of elderly male patients (≥60 years) were selected using the consecutive sampling technique who met the inclusion and exclusion criteria. Performed total testosterone test and TEWL level examination by using Tewameter to the research sample. Results: The Total testosterone levels of the patient were ranged from 146.11 - 575.10 ng/dL with a mean of 351.67 ng/dL and standard deviation of 116.34. The TEWL level of the patients was ranged from 17.2 - 50.8 g/jam/m2 with a mean of 31 g/jam/m2 and standard deviation of 9.20. The correlation coefficient value between total testosterone and TEWL was -0.853 with a significance of 0.0001 (p <0.05). Conclusion: There was a significant relationship between total testosterone and TEWL. Lower testosterone levels were consistently associated with higher TEWL values, indicating a measurable decline in skin-barrier function.