Objectives: Laser treatment, ablative and non-ablative as monotherapy or in combination can represent a meaningful treatment option in selected cases. We tried to summarize results of scientific studies prooving the effect of lasers for the Treatment of NMSC esp. BCC
Introduction: With a clear increase in the incidence and a continuously earlier onset, the Treatment options for localized resectionable basal cell carcinoma include micrographically controlled surgery, simple excision, curettage, laser ablation, nonsurgical treatment options are more suited for cases in which surgical procedures lead to disfigurement or functional impairments or for patients with a high surgical risk. Among them are cryosurgery, imiquimod, 5-fluorouracil, photodynamic treatment and radiotherapy and lasers
Materials / method: In pub med and multiple journals we searched fort he use of lasers in NMSC , esp. BCC, their paramenters and results.
Laser ablation with Er:YAG and CO2 lasers continues to be of interest as a potentially less invasive alternative to surgery for the treatment of low-risk superficial and nodular subtypes of BCCs. The lack of histopathological confirmation has been a limitation but a reflectance confocal microscopy (RCM) imaging-guided approach offers cellular-level histopathology-like feedback directly on the patient.Ablative fractional lasers (AFXL) enhance uptake of topical therapeutics a
Results: Non ablative laser procedures can also be effective, easy to perform and inexpensive as well as associated with little side effect and almoast no downtime.
Pulsed dye lasers (PDL) produce intravascular thrombus formation without epidermal and dermal damage; histological studies immediately after treatment show agglutinated red blood cells, fibrin and platelet thrombin confined to the blood vessels of the papillary and mid reticular dermis, BCC is a vascular dependent lesion, hence the utility of PDL Treatment The Nd:YAG (1064 nm) laser is more highly absorbed in blood than in the surrounding
Conclusion: There already is increasing evidence about the effects of laser treatment of basal cell carcinoma; nevertheless, further studies with a high level of evidence are necessary.
Декларация COI
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