摘要

Objectives: The study examined the clinical outcomes of a multicentric, observational, retrospective, case-series investigation in which Microneedling (MND) with Low-Level Led Therapy (LLLT) and Growth Factors (GFs) as Platelet-Rich Plasma (PRP) were applied to patients suffering from androgenic alopecia (AGA) Introduction: A procedure based on Microneedling (MND) with Low-Level Led Therapy (LLLT) and Growth Factors (GFs) such as Platelet-Rich Plasma (PRP) could be a booster for hair re-growth (HRG) in patients affected by Androgenetic Alopecia (AGA). Materials / method: Twenty-one patients were initially enrolled, of which seventeen males were classified in stage II-IV by the Norwood–Hamilton scale, and four females were classified in stage I by the Ludwig scale. One male patient was excluded after screening (exclusion and inclusion criteria evaluation). Twenty patients were analyzed. Hair regrowth (HRG) assessment was evaluated with photography, physicians, and patient’s global assessment scale, in addition to standardized phototrichograms during a follow-up: T0—baseline, T1—20 weeks (wks), T2-48 wks, and then annually. Results: A statistically significant improvement in HRG (p = 0.0822) and an increase in hair density of 19 +/- 2 hairs/cm2 at T1 after 20 wks (20 wks vs. 0 wks) in the a targeted area over baseline (74 +/- 2 hairs/cm2 at T1 versus 55 +/-2 hairs/cm2 at baseline) were reported and described as encouraging results. Conclusion: The effectiveness of MND with LLLT and GFs use was demonstrated in AGA patients.