摘要

Objectives: Younger subjects tend to exhibit faster onset and better outcomes for botulinum toxin injections, threads, energy-based devices, and bio-stimulator injections. Therefore, this study explored the viability of rejuvenating skin conditions using exosomes to create a more receptive environment before conventional non-invasive procedures. Introduction: In the last 20 years, with the introduction of Botulinum Toxin type A to treat facial wrinkles, the non-invasive aesthetic market has exploded, giving birth to the availability of a range of products, including fillers, threads, skin boosters, energy-based devices, and bio-stimulators. Recently, exosomes have gained much attention for their effects on facial rejuvenation. Exosomes have been cited to promote the synthesis and function of the extracellular matrix, the most significant component of healthy and youthful skin. Materials / method: In this study, subjects were first treated with exosomes using a micro-needling device and delivery system that uses CO2, cold temperature, and pressure. After three weeks, the subjects were evaluated using a skin analyzer. Results: The skin analyses three weeks after the application of exosomes showed 20% improvements in skin age, confirming the viability of combining exosomes as a pre-treatment protocol to create a more enriched environment for better outcomes for subsequent non-invasive procedures. Conclusion: Subsequent split-face studies exploring the combination of exosomes as a pre-treatment protocol with the intradermal injection of botulinum toxin confirmed the viability of the claims made in this study. Further studies are required to explore the best protocol timeline for each non-invasive procedure and interactions with energy-based devices.