摘要

Objectives: The objective of this split-face study was to determine whether topical application of a novel multiple-active emulsion moisturizer before, during and up to 7 days after microneedling treatment can resolve inflammation and accelerate wound healing in adults with healthy skin to amplify luminosity and reduce erythema and tactile skin texture over 28 days, compared to conventional microneedling protocol with a hyaluronic acid serum vehicle control. Introduction: Introduction: Microneedling is a cosmetic procedure that leverages the skin’s natural ability to heal in order to promote collagen formation and skin rejuvenation. To provide improved results, the technique can be combined with topical skin treatment formulations. A new formulation of multiple actives, including omega-3 (n-3) polyunsaturated fatty acids (PUFAs), was designed to accelerate the resolution of inflammation and wound healing following microinjury treatments, while enhancing the visible appearance of procedure results, including erythema, luminosity and skin texture. Materials / method: In this randomized, controlled, split-face study, we examined 32 healthy female participants aged 30–70 years for 4 weeks following microneedling treatment with a novel, multiple-active aqueous formulation versus conventional microneedling protocol with a hyaluronic acid control serum. Changes in skin condition were assessed by blinded clinical photography and expert evaluation. Measurements were collected at baseline, 1 h, 1 day,7 days and 28 days post treatment. Results: Significantly greater improvements in expert-assessed erythema, luminosity and skin texture were reported following application of the novel multiple-active-ingredient formulation than with the hyaluronic acid control serum. The data support topical application of a novel multiple-active-ingredient formulation in combination with microneedling for accelerating inflammation resolution and subsequent wound healing in female adults with healthy skin; however, further evaluation among adult male subjects with healthy skin is needed to ensure broader efficacy Conclusion: These data provide new evidence for the role of a novel multiple-active-ingredient formulation for improving skin outcomes up to 28 days following microneedling in adults with healthy skin when compared with a hyaluronic acid serum. The n-3 PUFA content of this formulation may drive accelerated inflammation resolution and wound healing alongside the complementary action of the other active ingredients, leading to the observed improvements in erythema, luminosity and skin texture.