摘要

Objectives: To establish if the combined use of fractional microneedling with radiofrequency and plant derived exosomes is an effective and safe treatment of melasma in Asian patients. Introduction: Melasma is a benign but psychologically debilitating skin condition that can affect Asian skin at a higher rate than Caucasian skin due to the higher melanin production in Asian skin. The skin condition is also more prevalent in women than men. Melasma also affects around 40% of women and 20% of men in Southeast Asia. Chronic ultraviolet (UV) exposure, genetic factors, and sex hormones are generally believed to be involved in the occurrence of melasma. Pathophysiology reveals that the basal basement membrane of melasma patients has been found to have a vacuolar structure within keratinocytes a Materials / method: Twenty patients with melasma underwent 3 sessions of fractional microneedling with RF all over the face followed by application of Exosomes 5cc 4-6 weeks interval. Responses to treatments were evaluated using the serial photography, Mexameter Melanin scores , MASI score, and the patient's overall assessment and satisfaction Results: Combination therapy showed marked improvement in the appearance and size of pigments an average decrease of 7-10.2 in Melanin Mexameter reading values and MASI score average decrease of 5-8 points after three treatment sessions. It is also worthwhile to note the improvement in skin texture and tightening among all subjects. Combination therapy showed a significant improvement of melasma with no remarkable side effects were reported. Conclusion: The combination treatment of fractional microneedling RF therapy and application of plant derived Exosomes showed a significant therapeutic effect for melasma. Therefore, the combination treatment could be a new and safe adjunct therapy for the treatment of melasma