摘要

Objectives: The objective is to establish a standardization of technologies that would best serve as drug delivery in each type of treatment for intimate rejuvenation, identifying the most suitable treatments for each condition. Introduction: The use of exosomes in dermatology, particularly in the treatment of genital areas, represents a significant innovation. This technology has shown potential in promoting skin regeneration, rejuvenation and a drug delivery, as well as in addressing specific conditions, including vulvar bleaching, hydration, skin tightening, vulvovaginal atrophy and specific conditions as scleroatrophic lichen. Materials / method: We divided the patients' concerns into the following topics:\ Vulvar Bleaching– microneedling or microneedling RF with exosomes combined with picosecond laser and peels Vulvar laxity – microfocused ultrasound and/or radiofrequency plus electroporation exosomes. Scleroatrophic lichen – CO2 laser and/or Erbium laser and/or radiofrequency with electroporation exosomes Vulvovaginal Atrophy – CO2 or Erbium laser and exosomes Improved Sexual Activity – radiofrequency with electroporation exosomes plus eletromagnetic field Stress Urinary Incontinence – CO2 or Erbium laser plus eletromagnetic fiel Results: The results are based on the authors' experience of over 10 years in this field and, in this case, on the use of exosomes in intimate rejuvenation for at least 10 months in conjunction with various technologies. The outcomes achieved surpassed those obtained when using the technologies individually and were rated as highly satisfactory by the patients when used with exosomes. No complications were observed in any of the treated cases with improvement outcome. Conclusion: The use of exosomes is growing in the field of dermatology, however, there is still a need to standardize their use when combined with the technologies. Therapies, when used in combination as described in the text above, demonstrate superior and more satisfactory results, when used individually. No complications were recorded.