Exosomes, a ray of hope for hair loss patients? Its limitation, evidence, and future in hair regeneration
Objectives: Topical minoxidil/ peptides and other oral medications has been a disappointment in patients with Hairloss . Here at this stage , Exosomes becomes as an effective and targeted therapy in hair loss patients and in long term maintenance proves itself to a promising treatment.
In the paper presentation I would be discussing on the the molecular mechanism of action of Exosomes with data available for its use in hairloss patients , along with few review of case studies in context to Indian patients .
Introduction: Exosome based therapy was used with Microneedling in 20 patients with Male Androgenetic Alopecia and Female pattern alopecia which showed significant decrease in hairloss and efficacious improvement in hair texture and in regrowth to quite an extent.
Materials / method: 2 male patients and 8 female patients with different grades of Androgenetic alopecia and female pattern alopecia were treated with micro needling along with Exosomes formulation with 2 sessions at a gap of 3 months. Patients were assessed using Hair Pull test, Global photographic assessment and Physician and patient subjective assessment scale at baseline and 3 months.
Results: Significant reduction in hairfall was seen in all the patients. Hair texture improvement was self noticed by the patients in 9 male patients and 6 female patients. New fine hair regrowth was seen in 17 out of 20 total patients which was seen as early as in 4-6 weeks on average . Subjective scoring by the patients and a blinded Objective scoring was done by a Dermatologist to assess the results in all the patients which showed improvement in most of the cases. There was slight pain and erythema in 3 out of total 20 patients .
Conclusion: Limitations - There are few biological, technological and regulatory issues that needs to be addressed before using exosomes which would be discussed in my paper presentation.
Conclusion -Microneedling along with Exosomes formulation is an effective , convenient and easy to perform procedure in comparison to other cell based therapies or mesotherapies. The results were faster as compared to other therapies. It is definitely an efficacious therapy but more trials and studies are needed to validate the same.
