Mixing hyaluronidase with HA filler is essential for its action
Objectives: To demonstrate that for hyaluronidase's effectiveness it is crucial to actively mix it with the hyaluronic acid filler. Relying solely on diffusion is insufficient to ensure the desired outcomes. This implies that the assurance of hyaluronidase effectiveness lies exclusively in ultrasound-guided injections.
Introduction: In our complication filler centre, we encounter patients who have previously been treated by their physicians with hyaluronidase for hyaluronic acid filler complications without success. However, in our clinical setting, ultrasound-guided injections have consistently proven to be successful. What accounts for this difference in outcomes?
Materials / method: We investigated the passive diffusion of hyaluronidase into the hyaluronic filler substance over a period of 24 hours.
Results: Our findings revealed that the hyaluronic acid filler was dissolved by hyaluronidase only after undergoing centrifugation.
Conclusion: In direct conclusion, our study underscores the critical importance of ultrasound-guided injections of hyaluronidase directly into the hyaluronic acid (HA) filler pocket.
