摘要

Objectives: This study aimed to evaluate the safety and efficacy of the use of FG-e-SVFs and FG-e-PRP in face rejuvenation and for soft tissue defect improvement. Introduction: Platelet-rich plasma (PRP) is a platelet concentrate that has widely been used to accelerate the healing of soft tissues. In traditional fat grafting prepared without the enrichment with PRP and/or stromal vascular fraction cells (SVFs), dissatisfaction in terms of unpredictable absorption rates, potential morbidities, and a lack of evidence regarding the long-term results prompted the author to describe the potential and efficacy of fat graft enhanced with adipose-derived stromal vascular fraction cells (FG-e-SVFs) and PRP (FG-e-PRP) in face soft tissue defects. Materials / method: 33 female patients affected by face soft-tissue defects with loss of volume, study group (SG), were treated with FG-e-SVFs. Clinical evaluation, a photographic assessment, magnetic resonance imaging (MRI), and ultrasound (US) were performed. Post-operative follow-up was performed at 1, 3, 7, 12, 24, 48, weeks, and then annually. 15 patients affected by soft-tissue defects were treated with FG-e-PRP. (SG-1) The results obtained in SG and SG-1 were compared with those of a control group (CG) (n = 30) treated with fat graft not enhanced (FG). Results: SG patients showed 61% maintenance of the contour restoring and volume after 3 years compared with the CG treated with FG, who showed 31% maintenance. 60.7% (n = 20) of SG patients, presented an increase of 6.6 mm in the soft tissue volume after 36 months, which was reported in only 33,3% (n = 10) of the CG. SG-1 patients showed 59% maintenance of the contour restoring and volume after 3 years compared with the CG treated with FG. Conclusion: The use of FG-e-SVFs and FG-e-PRP was safe and effective in this series of a case treated.