摘要

Objectives: The objective was to evaluate the durability of results from combined therapy using botulinum toxin and exosomes for treating large pores, skin flushing, and pigmentation, up to 18 months post-treatment. Introduction: This study tracked participants over 18 months to gauge the efficacy of combined therapy for diverse skin issues. Initial positive outcomes after two sessions prompted further investigation into the sustainability of results. Materials / method: Participants received combined botulinum toxin and exosome therapy targeting pore size, flushing, and pigmentation. Treatment involved two sessions: the first utilizing insulin syringe air dissection and micro-droplet botulinum toxin, the second employing microneedle therapy (MTS) and exosomes. Treatment efficacy was assessed using 3D camera analysis over the 18 months. Results: Following two sessions, patients experienced significant improvement in skin texture and pigmentation at the six-month mark, indicating satisfactory outcomes. Combining botulinum toxin and exosome therapy stimulated collagen production and enhanced dermal tissue, resulting in lasting skin enhancements. Analysis revealed these improvements persisted for 18 months post-treatment, suggesting long-term efficacy. Conclusion: This study highlights the sustained effectiveness of combined botulinum toxin and exosome therapy for addressing skin pore, flushing, and pigmentation concerns. The treatment's regenerative effects, including enhanced collagen production and tissue improvement, led to enduring enhancements in skin quality. These findings support the long-term use of combined therapy for various skin issues.