摘要

Objectives: Existing studies often experiment with restricted parameters, such as single wavelength, spot size, energy density, or pulse duration. Given the potential for different penetrative depths and interactions with chromophores under combined exposure of long pulsed 1064nm & 755nm, our hypothesis posits that the alexandrite laser may offer further regenerative benefits, contributing to an overall improvement in facial contour, skin laxity, uneven skin tone, and erythema. Introduction: The long-pulsed neodymium-doped yttrium aluminum garnet (Nd:YAG) laser has a well-established track record of safety and efficacy in addressing key manifestations of photoaging, including wrinkles, sagging, skin laxity, erythema, uneven texture, and pigmentation. Its specific wavelength of 1064 nm enables profound dermal photothermal damage, leading to enhanced collagen synthesis and dermal remodeling. Although long-pulsed alexandrite laser lacks sufficient data on its effectiveness in skin rejuvenation, it is widely used for treating vascular conditions, benign skin lesions, and hair removal. Materials / method: The purpose of this study is to evaluate the safety and efficacy of addressing different skin layers and chromophores using a dual-wavelength long-pulsed laser (755 and 1064 nm) for treating facial contour, laxity, uneven skin tone, and erythema. A total of 20 participants aged 40–65 years with Fitzpatrick phototype III-IV were enrolled. The study utilized a dual-wavelength long-pulsed alexandrite and Nd:YAG laser. 4 sequential laser parameters were applied in a single treatment session over the full face. Follow-ups were conducted at 2 weeks and 1 month following treatment. Results: The dual-wavelength long-pulsed 755 nm/1064 nm laser demonstrates significant improvement in facial contour, skin laxity, erythema, and uneven skin tone. At 2 weeks, 92% of participants noted improvement to a certain extent (grade 5 or higher on a 10-point PSI scale) in facial contouring and skin laxity, with 70% and 100% reporting improvements in erythema and uneven skin tone, respectively. By 1 month, a decline in PSI was observed to 60%, 66%, 66%, and 47% for the four outcome measures. Pain during the procedure was generally well tolerated, with participants reporting mild to moderate. Conclusion: In conclusion, the dual-wavelength long-pulsed alexandrite and Nd:YAG laser offer safe and effective solutions for addressing aged contour, laxity, uneven skin tone, and erythema. Although the effects persist over a 1-month period, the decline in PSI suggests the need for further maintenance sessions.