摘要

Objectives: Exhaustive and concrete overview of current and future toxins. Examine the benefits and limitations of current toxins as well as the promises of future ones. Introduction: Botulinum neurotoxins (BoNTs) have intrigued scientists and clinicians for decades due to their potency, selectivity, and duration's action. These features separate them from many other therapeutics and continue to stimulate innovation in both basic and clinical research. Since its introduction as a treatment for strabismus, botulinum toxin (BoNT) has had a phenomenal journey. Synthetic BoNTs and BoNTs from non-clostridial sources are not far from clinical use. Moreover, the study of mutations in naturally occurring toxins has led to modulation in the toxo-pharmacokinetic properties. Materials / method: Scientific published studies overview; Full Pubmed/Medline last publications Results: A number of innovative BoNT formulations have been developed in the last few years. In addition to the naturally derived products, synthetic, genetically engineered products are also now studied. There are some differences in the pharmacological profile of the formulations currently available and expected... Specially in terms of target, potency or duration... Conclusion: Currently, there are more than eight different botulinumtoxin formulations approved for clinical use, and more are in the pipeline. This review simplifies the pharmacological profiles and characteristics diferenciation of current and newer BoNTs. Physicians should be aware of this to propose the optimal BoNT "solution" regarding the aesthetics goals and and patient requirements.