摘要

Objectives: This presentation aims to review the current literature on the use of polynucleotides in various dermatological conditions and share clinical insights from real-world applications. Introduction: Polynucleotides (PNs) have gained attention in dermatology and aesthetic medicine due to their regenerative properties, enhancing tissue repair, hydration, and collagen synthesis. When combined with hyaluronic acid (HA) and mannitol, their efficacy in skin rejuvenation and wound healing may be further optimized. Materials / method: A comprehensive literature review was conducted to assess the efficacy of polynucleotides in different skin conditions, including aging, scarring, and post-procedural healing. Additionally, a clinical protocol incorporating polynucleotides, HA, and mannitol will be presented alongside notable case studies demonstrating patient outcomes Results: Emerging evidence supports the role of polynucleotides in improving skin quality, reducing inflammation, and enhancing cellular repair. Our clinical experience further highlights their potential in optimizing treatment outcomes in aesthetic and therapeutic dermatology. Conclusion: Polynucleotides, in combination with HA and mannitol, offer a promising approach for skin therapy. This session will provide an evidence-based review and practical guidance for incorporating these agents into clinical practice.