摘要

Objectives: Probiotic-derived exosomes have emerged as a promising therapeutic innovation in dermatology, particularly for addressing sensitive pigmented skin. This case report evaluates the application of Lactobacillus-derived exosomes in ten Indonesian patients (aged 19-45 years) with Baumann's sensitive-pigmented skin type. Introduction: The interaction between exosome-delivered components and the skin’s resident microbiome can promote a synergistic effect, enhancing dermal remodeling, reducing inflammation, and improving barrier function. Materials / method: Ten patients with Fitzpatrick skin type 4-5 (2 males and 8 females, aged 19 to 45 years) with Baumann's sensitive-pigmented skin type, as determined through a self-filled questionnaire, 10 were enrolled in this study. None of the participants had undergone prior facial dermatological treatments. Each patient received a topical application of 2 ml of a product containing Lactobacillus-derived exosomes immediately after undergoing fractional picosecond 755 nm laser sessions. Results: Objective evaluations demonstrated significant improvements in skin texture and pigmentation uniformity, while subjective assessments confirmed reduced sensitivity and increased patient satisfaction. The results underscore the therapeutic potential of probiotic-derived exosomes in managing complex skin types, providing both functional and aesthetic benefits. Conclusion: Combining probiotic-derived exosomes with fractional picosecond laser technology has proven to be a safe and effective way to care for sensitive pigmented skin. This approach not only helped restore the skin barrier but also promoted noticeable dermal remodeling, improving both the skin’s appearance and function.