摘要

Objectives: To demonstrate the clinical efficacy of Smart Combination Therapy—integrating PEGylated HA fillers, non-crosslinked HA with CaHA, and laser treatment—in addressing facial rejuvenation and acne scar improvement. Through two distinct cases, this study highlights how a personalized, minimally invasive approach can optimize outcomes, enhance skin quality, and reduce product use while achieving natural, long-lasting aesthetic results Introduction: As aesthetic medicine continues to evolve, the focus has shifted toward combining modalities to enhance both structure and skin quality. This presentation introduces Smart Combination Therapy, which integrates PEGylated HA fillers, non-crosslinked HA with CaHA, and laser treatment. Through two clinical cases, we explore how this strategic, minimally invasive approach can deliver natural, long-lasting results in facial rejuvenation and acne scar treatment. Materials / method: Two patients were treated using Smart Combination Therapy. Case 1 involved facial rejuvenation using non-crosslinked HA with CaHA and PEGylated HA fillers in two phases—hydration and structural enhancement. Case 2 focused on acne scar treatment using PEGylated HA filler injection followed by fractional laser resurfacing. Techniques, product selection, and injection planes were customized based on individual facial anatomy and treatment goals. Results: Case 1 showed visible improvement in midface volume, tear trough, and jawline definition with sustained results at 11 months. Case 2 demonstrated significant reduction in acne scar depth, improved skin texture, and hydration at both 1- and 6-month follow-ups. Both cases achieved natural-looking outcomes with minimal product use and downtime, supporting the effectiveness of a layered, combination approach in aesthetic treatment. Conclusion: Smart Combination Therapy offers a strategic and efficient approach to facial rejuvenation and scar treatment. By integrating PEGylated HA fillers, non-crosslinked HA with CaHA, and laser technology, natural and long-lasting results can be achieved with less product and downtime. These cases highlight the importance of individualized treatment planning and modality synergy in modern aesthetic practice