摘要

Objectives: To present current evidence and clinical outcomes supporting microneedling as a regenerative treatment for hair loss. Attendees will learn underlying mechanisms (angiogenesis, neocollagenesis, drug delivery), indications in androgenic and post-menopausal alopecia, and practical considerations for device selection, treatment intervals, and patient tolerance. Introduction: Hair loss affects both sexes and increases with age. Androgenic and post-menopausal alopecia are prevalent and often multifactorial, driven by hormonal, vascular, and inflammatory factors. Microneedling has emerged as a minimally invasive option that enhances follicular microenvironment, angiogenesis, and topical agent penetration with favourable safety and minimal downtime. Materials / method: Professional microneedling was performed on the scalp with standardized needle depth matched to scalp region. Patients underwent multiple sessions at defined intervals. Mechanistic evaluation included angiogenesis and neocollagenesis data from histology. Clinical evaluation included images, global assessment, and subjective tolerance. Adjunctive hair growth topicals were used in some cases. Results: Microneedling demonstrated improvements in scalp vascularity and extracellular matrix markers, supporting regenerative activity. Clinically, patients showed visible increases in hair density, volume, and growth after treatment courses. Improvements were observed in both male androgenic alopecia and post-menopausal hair loss. Tolerance was high with minimal downtime and no serious adverse events. Conclusion: Microneedling is a promising regenerative treatment for hair loss, enhancing follicular environment, angiogenesis, and transdermal delivery while maintaining a favourable safety profile. Visible clinical improvements and strong patient tolerance position microneedling as a viable stand-alone or adjunctive modality in androgenic and post-menopausal alopecia.