摘要

Objectives: To describe unconventional approaches to treat patients affected by hidradenitis suppurativa Introduction: Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder characterized by painful nodules, abscesses, and sinus tracts primarily affecting apocrine gland–bearing areas. Standard management often includes biologic drugs and surgery; however, emerging treatments such as photodynamic therapy (PDT), laser interventions, and botulinum toxin injections are gaining attention as complementary options. This abstract aims to evaluate the role of these novel therapies in HS management. Materials / method: A literature review was conducted focusing on studies exploring PDT, various laser modalities, and botulinum toxin use in HS patients. Clinical outcomes, safety profiles, and comparative effectiveness with standard therapies were analyzed. Emphasis was placed on assessing the mechanisms by which these treatments may reduce inflammation, bacterial colonization, and disease severity, alongside their potential to improve quality of life. Results: PDT, lasers, and botulinum toxin represent promising adjunctive treatment options for patients with HS, particularly in cases refractory to standard biologic therapies or when surgery is contraindicated or incomplete. PDT and lasers offer targeted reduction of inflammation and bacterial load, while botulinum toxin may decrease sweat gland activity contributing to disease pathogenesis. Conclusion: These therapies can optimize patient outcomes when integrated into a multidisciplinary management plan. Further controlled studies are warranted to standardize protocols and confirm long-term efficacy.