摘要

Objectives: To assess the clinical efficacy and safety of GD tone-up therapy in reducing pigmentation in patients with localized hyperpigmentation Introduction: Pigmentary disorders such as melasma and post-inflammatory hyperpigmentation are frequent dermatologic concerns that are often resistant to conventional management. Laser- and energy-based devices provide therapeutic options but may be limited by adverse effects or inconsistent outcomes. GD tone-up is a novel photobooster agent designed to modulate pigment through a combination of a microdermabrasion effect as well as a photothermal effect coupled with brightening ingredients to enhance the effect of laser treatment. Materials / method: Six patients (all females; mean age 36 years, range 28–46) with clinically diagnosed melasma or post-inflammatory hyperpigmentation were enrolled. Each received up to four sessions of GD tone-up therapy at 4-week intervals. Efficacy was evaluated using standardized clinical photography and modified Melasma Area and Severity Index (mMASI) scores at baseline, immediately after treatment completion, and four weeks post-treatment. Patient-reported satisfaction was recorded using a 5-point Likert scale. Safety was assessed by monitoring adverse events during and after sessions. Results: All six patients demonstrated clinical improvement in pigmentation. Mean mMASI scores decreased by more than 40% compared to baseline, with maintenance of improvement at four-week follow-up. High satisfaction was reported, with an average rating of 4.3/5. No major adverse effects occurred. Mild transient erythema and dryness were observed in two patients, resolving spontaneously within 48 hours without intervention. Conclusion: GD tone-up demonstrated favorable outcomes in pigment reduction and patient satisfaction, with minimal adverse events in this preliminary series. The results support its potential as a safe and effective modality for pigmentation management. The addition of a photobooster has shown to enhance the treatment by lasers and can be considered as an adjunct in the management of facial hyperpigmentation.