摘要

Objectives: Recent advances in chronobiology have revealed that the skin possesses its own circadian clock, regulating key physiological processes such as epidermal proliferation, barrier repair, melanin synthesis, and inflammatory responses. These rhythms play a critical role in maintaining skin quality and resilience, and disruptions—whether due to aging, environmental stressors, or irregular lifestyles—can accelerate cutaneous aging and compromise aesthetic outcomes. Introduction: Emerging evidence highlights that skin of colour, including Asian skin, may exhibit distinct circadian dynamics in pigmentation, transepidermal water loss, and inflammatory signaling, influencing both the baseline skin condition and its response to aesthetic procedures. Materials / method: This presentation explores the molecular crosstalk between core clock genes and skin homeostasis, with a focus on how circadian biology modulates outcomes of treatments such as laser resurfacing, microneedling, and topical therapeutics. Understanding these rhythms may provide a framework for optimizing procedural timing, enhancing skin healing, and minimizing post-inflammatory hyperpigmentation —especially in patients with higher Fitzpatrick skin types. Conclusion: By integrating circadian biology into dermatologic and aesthetic practice, we propose a precision-timed approach to improve long-term skin health and procedural success in diverse patient populations.