摘要

Objectives: The objective is to evaluate the safety and efficacy of combining microneedling with topical insulin infusion and biofiller for atrophic acne scar correction. The protocol aims to enhance collagen production, improve scar depth and skin texture, and provide immediate volumization with biofiller. Outcomes are assessed using Goodman and Baron grading, photography, and patient satisfaction, while monitoring safety and tolerability of this novel, synergistic treatment approach. Introduction: Atrophic acne scars are a common yet challenging concern in aesthetic dermatology, often requiring multimodal treatments for optimal results. Traditional microneedling induces neocollagenesis through controlled dermal injury, while recent evidence suggests that adjunctive therapies can further enhance outcomes. Intradermal insulin, with its anabolic and growth-promoting properties, and biofiller (autologous plasma gel) offer regenerative potential when integrated with microneedling. Materials / method: 15 patients aged 20 - 40 years with Goodman and Baron grade II - III atrophic facial acne scars underwent three sessions at 4-week intervals. Each session included: • Microneedling (1.5 mm depth) with simultaneous topical application of regular diluted insulin (1-2 ml) to enhance transdermal delivery. Intradermal injection of biofiller post-needling for volumization and collagen stimulation. Patients were evaluated using standardized photography, Goodman and Baron quantitative grading, and patient satisfaction surveys at baseline and 12 weeks post-final session. Results: Significant improvement in scar depth and skin texture was observed in 84% of patients, with a mean reduction of one grade on the Goodman and Baron scale. High patient satisfaction (score ≥ 8/10) was reported, with no major adverse events beyond transient erythema and edema. Conclusion: Microneedling combined with intradermal insulin and biofiller represents a safe, cost-effective, and synergistic approach for atrophic acne scar correction. This presentation will detail the protocol, technique pearls, and real-world outcomes for practitioners seeking advanced scar management strategies.