摘要

Objectives: To explain how microfocused ultrasound and calcium hydroxylapatite can be combined for structural facial rejuvenation, focusing on collagen stimulation, tissue tightening, and restoration of facial support using a synergistic and layered approach. Introduction: Facial aging is a progressive process that affects the skin, fat, ligaments, and bone. There is loss of collagen and elastin, reduction of skin thickness, and decrease of mechanical support. These changes lead to sagging, wrinkles, and loss of facial contour. Treatments that act on both tissue structure and biological activity are therefore needed. Materials / method: A review of clinical and histological studies on microfocused ultrasound with visualization (MFU-V) and calcium hydroxylapatite (CaHA) was performed. The mechanisms of action, treatment depth, sequencing, and dilution protocols were analyzed to define evidence-based strategies for combined use in facial rejuvenation. Results: MFU-V produces controlled thermal points in the deep dermis and SMAS, leading to collagen contraction and new collagen formation. CaHA stimulates fibroblasts through mechanotransduction and promotes long-term production of collagen, elastin, and new blood vessels. The combined treatment shows better improvement in skin firmness, thickness, and facial contour than each method alone. Conclusion: The association of MFU-V followed by CaHA offers a safe and effective regenerative approach for facial rejuvenation. This combination restores mechanical support and improves the extracellular matrix, providing natural and long-lasting structural and skin quality improvement.