摘要

Objectives: To evaluate the role of photothermally conditioned Platelet-Rich Plasma (PRP) as a regenerative, non-thermal modality in vaginal rejuvenation, and to highlight its clinical applications, treatment protocols, and outcomes in improving vaginal health and function. Introduction: The paradigm of vaginal rejuvenation is shifting from structural correction to functional restoration, increasing the demand for regenerative and minimally invasive therapies. Conventional modalities such as lasers and radiofrequency primarily utilize thermal effects to induce collagen contraction and neocollagenesis, which offer structural improvement but limited cellular regeneration. Photothermally conditioned PRP represents an emerging non-thermal approach focused on tissue bio-stimulation through activation of cellular repair and regenerative pathways. Materials / method: Photothermally conditioned PRP is prepared and administered to target vaginal tissues to stimulate fibroblast activity, promote angiogenesis, and enhance extracellular matrix remodeling. The approach emphasizes physiological restoration of tissue health. Clinical application involves careful patient selection, particularly those seeking non-hormonal and non-thermal treatment options, followed by minimally invasive administration protocols required. Results: In clinical practice, photothermally conditioned PRP has demonstrated encouraging outcomes in the management of genitourinary syndrome of menopause (GSM), vaginal laxity, vaginal burning, and dyspareunia. Patients show improvement in vaginal mucosal health, elasticity, and hydration. The procedure is well-tolerated, minimally invasive, and associated with minimal downtime. Conclusion: Photothermally conditioned PRP as compared to conventional PRP represents a significant advancement in aesthetic and functional gynecology by promoting true tissue bio-stimulation rather than mere structural enhancement. This approach supports sustained tissue regeneration, improved vaginal function, and enhanced quality of life, marking a shift toward more physiological and patient-centered treatment strategies .