摘要

Objectives: By the end of the session, attendees will be able to: 1. Understand the biochemical process of glycation and the formation of Advanced Glycation End-products (AGEs). 2. Recognize the impact of glycation on the skin, including its role in collagen degradation, skin aging, and dullness. 3. Identify key internal and external sources of glycation that accelerate skin aging. 4. Explore topical and oral strategies, including skincare ingredients and supplements, that can help combat glycation and protect skin integrity. Introduction: Glycation is a silent, intrinsic aging process that occurs when sugars bind to proteins, lipids, or nucleic acids, leading to the formation of Advanced Glycation End-products (AGEs). While often discussed in the context of diabetes and chronic disease, glycation also plays a significant role in skin aging, affecting elasticity, firmness, tone, and overall skin health. Conclusion: Glycation is a key, but often overlooked contributor to extrinsic and intrinsic skin aging. Its ability to stiffen collagen, generate oxidative stress, and impair the skin’s repair mechanisms makes it a prime target for proactive intervention. Through an evolving body of research, we now have a clearer understanding of how to slow and combat glycation. By integrating these tools into patient care, we can offer more targeted strategies for maintaining youthful, resilient skin in the face of both time and lifestyle stressors.