RED：一款富含胶原蛋白的综合性眼周护理疗程

目标: To develop a convenient method in periodical collagen redjuvenation 介绍: The periorbital area is one of the first to show aging signs, such as pigmentations, wrinkles, puffiness, and fine lines, affecting both appearance and health. This study presents a novel three-step collagen-enhanced treatment for periorbital rejuvenation. 材料 / 方法: Forty-three Chinese Han female patients aged 25–55 years with periorbital pigmentation, tear trough deformity or fine lines were treated with a collagen injection technique. Two independent physicians assessed the severity of periorbital aging before injection and 3, 6, and 12 months later, according to the Barton scale and tear trough rating scale (TTRS). Primary outcomes, including changes in pigmentation and capillary density, were analyzed using 3D reconstruction software. Additionally, patient questionnaire FACE-Q scores and adverse reactions were also recorded. 结果: All patients achieved satisfactory aesthetic outcomes with no significant adverse events. Transient bruising and edema were the only side effects, and no abnormal lab results were observed. Compared to before the injection, the Barton scale and TTRS scores indicated significant improvements in the tear troughs, dark circles, and fine lines around the eyes at 3 and 6 months post-injection (P < 0.05). Before the injection, the periorbital pigmentation indices on the left and right sides were 22.88±5.04 and 25.21±4.54, respectively. 总结: The three-step collagen injection method effectively addresses periorbital deformities, demonstrating high patient satisfaction and a favorable safety profile.