Objectives: 1). To characterise the skin microbiome
2). To examine how the microbiome differs between dry and non-dry skin
3). To understand how the skin microbiome changes in response to treatment
Introduction: Considerable work has been invested in understanding the composition of the skin microbiome, how this differs between body sites and changes in medical conditions.
However, despite its high prevalence in society, little work has been undertaken to investigate the microbiome of dry skin and to understand how this changes in external challenges.
Materials / method: Cohort studies were undertaken in two geographically distinct locations (European
and North American) wherein a total of 222 subjects were recruited and lower leg skin classified as dry or non-dry based on visual assessment. Microbiome protocols employed to extract and analyse the microbial 16S rRNA gene prior to taxonomic, diversity and network analysis of microbiome data.
Results: All measures revealed a high degree of consistency between the two geographic cohorts. Staphylococcus, Cutibacterium, and Corynebacterium were the dominant genera in both cohorts and both skin types. Significant differences in microbiome diversity were observed using some metrics and microbiome network analysis demonstrated that in both cohorts the microbiome of dry skin exhibits decreased connectivity and resilience relative to that of non-dry skin.
Conclusion: This is the first study of the dry skin microbiome to compare large cohorts of subjects across multiple geographies. In contrast to previously published studies which used small cohorts, this study found no difference in α-diversity between dry and normal skin. Instead, this study found clear and consistent differences in microbiome β-diversity and network co-occurrence. These changes suggest that the microbiome of dry skin is compromised, exhibiting decreased connectivity and increased fragility relative to the microbiome of non-dry skin.
利益冲突声明
您有否接受任何资金来支持研究这个主题？
是
请注明名称（个人，公司，学会等等）: Research supported by Unilever R&D
您是否接受过关于这项研究的任何酬金或其他报酬？
是
请注明名称（个人，公司，学会等等）: Salary as an employee of Unilever
你是否和任何与您的研究所涉及的药物，材料或工具有密切联系的实体存在财务关系？
是
请注明名称（个人，公司，学会等等）: Unilever R&D
你是否拥有或者您已经为您此研究中的工具，药物或材料申请任何专利？
否
这项工作的完成感谢以下机构的支持： Unilever R&D
