Headquartered in the San Francisco Bay Area, R2 Technologies was founded in 2014 by Pansend LLC, the life sciences segment of INNOVATE (NYSE: VATE), Blossom Innovations, LLC, and Massachusetts General Hospital to develop a technology based on their patented method of Cryomodulation™. In 2019 R2 brought on strategic partner, Huadong Medicine Co., Ltd. Since then, R2 has been developing an innovative product pipeline featuring the GLACIAL® portfolio of CryoAesthetics™ devices, including Glacial Rx and Glacial Spa. The GLACIAL® platform for precision cooling of the skin has been shown to reduce inflammation, brighten dark spots, and minimize pain and thermal injury from lasers and other dermatological treatments.