Abstract

Objectives: 1. Define skin rejuvenation and skin boosters 2. Understand the mechanism of action of Polydeoxyribonucleotides for facial rejuvenation 3. Identify different methods of transdermal delivery of Polydeoxiribonucleotides Introduction: Polydeoxyribonucleotide or PDRN is a DNA-derived drug consisting of a mixture of double-stranded deoxyribonucleotides with a chain length of 80–2,200 base pairs with a molecular weight ranging from 50-1500 kDa. PDRN is extracted and purified from the sperm cells of Oncorhynchus mykiss, commonly known as salmon trout, which provide high-quality DNA without immunological side effects. Initially intended for tissue regeneration for chronic non healing wounds, its regenerative properties paved its way to be utilized in the field of medical aesthetics and dermatology for skin rejuvenation. Materials / method: The use of various microneedling instruments, followed by topical application of PDRN or a PDRN cocktail combined with growth factors, peptides, vitamins and non-cross linked hyaluronic acid are performed by clinicians for better skin penetration. Another method is the use of a multi suction injector which aims to combine microneedling with mesotherapy principles. Results: The device allows advanced solution delivery with a 9-pin multi needle and vacuum function to minimize the leakage of solution, minimize pain and shorten treatment time. Conclusion: Hence, the delivery of PDRN into the skin using a multi suction injector is more precise and the potential leakage is prevented.