Abstract

Objectives: The study provides an updated account of genetic factors associated with the extended lifespan and their interactive contributory role with cellular pathways with gene and advance Hybrid therapy in clinical practice including with epigenetics modification for prevention environmental factors which constraints of genetics to either protect or predispose to degenerative diseases. Introduction: Centenarian longevity is determined by the inherit genes. Some genes promote longevity, including those that encode antioxidant enzymes and heat-shock proteins. Other genes that are associated with serum lipid levels, glycation reaction, repeated inflammation process and immune systems contribute significantly to longevity. Aging is a multifactorial and complex process represented by low energy levels, stress induced loss of homeostasis leading to the risk of diseases and mortality, the functional decline of tissues and organs due to changes in molecular composition and physiology of cells. Materials / method: The trial in clinical practice to achieve centenarian longevity with gene and advance Hybrid therapy by promoting longevity gene and prevent risk factor that contribute inflammation and degeneration process by gene therapy with stem cell and chorion exosome intramuscular therapy, Metallothionein 1,2,3 (MT1,2,3) intramuscular therapy ,increasing energy level of cells by NAD intravenous infusion, reduce stress of cells,balance homeostasis and deglycation of cell by intravenous multivitamins ,intravenous minerals, deglycating molecules and antioxidation molecules including TMS and biofeedback. Results: After 6 months of gene and advance Hybrid therapy protocol with stem cell and chorion exosome intramuscular therapy, Metallothionein 1,2,3 (MT1,2,3) intramuscular therapy ,increasing energy level of cells by NAD intravenous infusion, reduce stress of cells,balance homeostasis and deglycation of cell by IV multivitamins ,intravenous minerals, deglycating molecules and antioxidation molecules including TMS and biofeedback for brain plasticity and regeneration.All of cases were improve in quality of life as increase of energy, improve of cognitive function, good mood and decrease sarcopenia. Conclusion: The gene and advance Hybrid therapy protocol with stem cell and chorion exosome intramuscular therapy, Metallothionein 1,2,3 (MT1,2,3) intramuscular therapy ,increasing energy level of cells by NAD intravenous infusion, reduce stress of cells, balance homeostasis and deglycation of cell by intravenous multivitamins ,intravenous minerals, deglycating molecules and antioxidation molecules including TMS and biofeedback for brain plasticity and regeneration could help to achieve centenarian longevity with good quality of life.