Systemic blood changes in skin hyperpigmentation

Objectives: to study systemic changes of blood counts in skin hyperpigmentation in comparison with the control group and their changes after treatment. Introduction: Acquired skin hyperpigmentations (AHH) are pathogenetically associated with increased melanocyte activity. However, the issue of formation of molecular mechanisms of occurrence is not fully disclosed. AHH are widespread in the population and significantly affect the quality of life of patients. It is known that one of the clinical signs of skin hyperpigmentation is localised hyperkeratosis in the lesion focus, associated with a high level of cell proliferation and cell saturation with melanin. A large amount of energy and substrates are required to maintain increased cellular metabolism. There Materials / method: The patient database was formed using MS Excel spreadsheets version 19.0 (manufactured by Microsoft, USA). Statistical analysis was performed using the IBM SPSS Statistical software version 26.0 (Manufactured in the USA). All the writing of the work, the creation of the database and the statistical analysis of the data were carried out on a personal computer. Quantitative indicators were evaluated for compliance with the normal distribution law using the Shapiro-Wilk criterion (for samples with fewer than 50 women) and the Kolmagorov-Smirnov criterion (for samples with more than 50 women). Results: It was found that in the red blood cells of women in the clinical group with skin hyperpigmentation, the concentration of pyruvic acid (PVA) was significantly reduced by 86% (the differences were statistically significant, p=0.03 according to the Mann-Whitney criterion) compared with the control group. At the same time, there was an increase in lactate levels by 167.4% relative to the control group. Thus, the level of cholesterol in patients with hyperpigmentation was statistically significantly different from the control, by 18.64%. Conclusion: The formation of skin pigmentation is considered as a physiological mechanism in response to inflammation, mainly associated with ultraviolet radiation. The general strategy of the inflammatory process under normal regulation and dysregulation has differences. It seems necessary to further study systemic adaptation mechanisms in dysregulation in patients with skin hyperpigmentation, as well as to reveal predictors contributing to its formation. The feasibility of studying the systemic biochemical profile in patients with skin hyperpigmentation will allow to develop optimal correction scheme.