Objectives: In this post-hoc analysis of the APPEAL study, we aimed to compare patient satisfaction, stratified by age and gender, after 3 injection cycles of abobotulinumtoxinA (aboBoNT-A) for the treatment of glabellar lines (GL).
Introduction: AboBoNT-A is a botulinum toxin type A (BoNT-A) that can be used to weaken muscle contraction to a therapeutic advantage. The short- and long-term efficacy of aboBoNT-A for treating GL is well established in clinical development studies. However, real-world data regarding patient beliefs and attitudes following long-term aboBoNT-A treatment, and whether they vary depending on age and gender, are limited.
Materials / method: The APPEAL study (NCT02353897) was a multicentre non-interventional, prospective, longitudinal study in patients with moderate-to-severe GL. Patients received 3 cycles of aboBoNT-A injections. The decision to receive aboBoNT-A must have been made prior to the decision to participate in the study. Overall satisfaction and factors associated with patient satisfaction (aesthetic outcome, self-perceived age, natural looks, self-esteem or desire to receive further injections) were assessed at 3 weeks (±7 days) after each cycle using a satisfaction questionnaire.
Results: Of 150 patients enrolled, 91.3% were women; the proportion for each age group (years) was: 18-30, 8.7%; 31-40, 21.3%; 41-50, 38.7%; 51-60, 22.7%; >60, 8.7%. After Cycle 3 (n=135), all except 1 patient, reported overall satisfaction with treatment. The proportion of ‘very satisfied’ patients was similar in 31-60 year-olds (73.7-76.0%), but higher in 18-30 year-olds and lower in >60 year-olds (80.0% versus 66.7%). All patients felt the results looked natural, and a greater proportion of women than men felt they looked ‘a little’ or ‘much’ younger than their age (92.9% vs 77.8% after Cycle 3).
Conclusion: This post-hoc analysis shows that regardless of patient sex and age at baseline, high levels of patient satisfaction can be achieved with aboBoNT-A injections for the treatment of GL. Interestingly, some differences were identified in factors affecting satisfaction between women and men, which supports an individualised treatment approach that should respect patients expectations and preferences.
Declaraciones
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Si
Por favor especifique las entidades (individuo, empresa, sociedad): Ipsen
¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No
¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No
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No
Este trabajo es presentado gracias al apoyo de: Ipsen