Objectives: androgenetic alopecia (AGA), commonly known as common baldness affects up to 80% of the general male population and 50% of the female population at some point in their lives.
Currently, the first-line treatments for AGA in men are oral antiandrogen drugs, 5-α reductase inhibitors. Likewise, Sabal serrulata has the ability to inhibit the two isoenzymes of 5-α reductase is active component of some cosmetic preperations.
The objective of this study is to verify the efficacy and safety of transdermal treatment of sterile cosmetic preparations already marketed and conveyed through microneedling
Introduction: Microneedling is a minimally invasive technique, which allows the opening of microchannels in the skin, favoring the topical absorption of sterile medical and/or cosmetic preparations. Its use is widespread in the treatment of different pathologies, including androgenetic alopecia (AGA).
The aim of the study is to assess the efficacy of microneedling in the treatment of AGA, by serial micropuncture, with commercial sterile cosmetic preparations.
Materials / method: Ten male volunteer patients diagnosed with AGA, were included in the study. They underwent 10 treatment sessions, performed weekly, using the microneedling technique followed by the application of 2 sterile topical cosmetic products containing Sabal serrulata and biomimetic growth factors. Daily home treatment with topical lotion and intake of a nutritional supplement was also prescribed.The following variables were considered:
- Average number of hairs per control area [N/cm2]
- Average hair shaft thickness [μm]
- Accumulated thickness of hair by surface area [mm/cm2]
- Sinclair scale
Results: At the 5th session, a reduction in hair loss was observed in all patients. The 60% presented a decrease in the AGA on the Sinclair scale, compared to the beginning of the treatment, which was objectified by trichogram. At the 10th session, 70% of the patients treated presented an improvement in cumulative hair thickness (mm/cm2).
Conclusion: Despite the limited number of patients, the transcutaneous administration of sterile topical cosmetics by microneedling together with home treatment could be a successful approach to androgenetic alopecia.
Declaraciones
¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
No
¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
Si
Por favor especifique las entidades (individuo, empresa, sociedad): toskani
¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No
¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No
Este trabajo es presentado gracias al apoyo de: toskani