Objectives: This lecture will demonstrate the possibility to treat different conditions of hair loss, regardless of the gender and age of the patient, using a customized protocol, composed by NAFL (density = 100 and energy = 20 J/ cm²), intra-dermal therapy with PRP and drug delivery with topical sterile formulations rich in vitamins, oligo minerals, botanical extracts, mainly high level of sillicium, combined with oral prescription of minoxidil, finasteride and dutasteride, when necessary. This study will show the safety and efficacy of these synergic techniques and technologies.
Introduction: Nowadays it is known that hair loss is a medical condition that can affect females and, mainly, males. Its most common cause is called Androgenetic alopecia, and it is known that approximately 50% of female and 80% of male experience significant hair loss during their lifetime. However, factors like stress, bad nutrition, hormones alterations, lack of sleep, smoking, menopause, post pregnancy and other disorders, such as Alopecia Areata, Telogen Effluvium, Senescent Alopecia, Female Pattern Hair loss, and Frontal Fibrosing Alopecia, can also provoke hair loss and shaft hair miniaturization.
Materials / method: The treatment, performed in more than 100 volunteers, consists in the application of LED/LLLT during twenty-five minutes, followed by NAFL 1565nm (100 spots/cm2 and 20 mJ) applied in horizontal, vertical and oblique lines on the scalp hair, between shaft hair, one centimeter apart each other. This protocol requires from five to ten sessions, with an interval of fifteen days. A blend of extracts, vitamins, amino acids, antioxidant and minerals was applied immediately after the laser or PRP by pneumatic platform or intradermal therapy with syringe.
Results: Pull test, biopsies of the affected area (pre and pos treatment) and polarized light microscopy were used to measure the thickness of the shaft hair, terminal vellus ratio, improvement of the miniaturization of the follicles and analysis of hair cycle using trichoscopy. It is possible to observe that all patients demonstrated an improvement after the treatment with this specific protocol, since the density of the hair shaft was 0.3mm, and after over 4 months of the procedure the analyzed structures became terminal hair with 0.6 mm big.
Conclusion: The main NAFL 1565 mechanisms of action for hair growth are based on the inducement and increase of blood flow, reduction of cytokines and changes of grow factors. It’s also possible to observe direct stimulation of dermal papilla. The key factors of hair growth and hair cycle are connected to the action of FGF family (VEGF, IGF and others grow factors), which are included in the wound healing process. The main factor for hair growth stimulation and hair cycle progress is the WNT-B-CATENIN-LEF1 signaling. No adverse effects were observed and the biopsies confirms the efficacy of the procedure.
Declaraciones
¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
No
¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No
¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No
¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No
Este trabajo no cuenta con el apoyo de ningún financiamiento directo o indirecto. El autor asume plena responsabilidad sobre el mismo.