Objectives: Vulvar fissures can occur for varied reasons and are frequently seen in clinical practice in menopausal patients with atrophy. In those patients who do not respond to the usual treatments, or have little response, repeated vulvar fissures can occur, which They trigger long-term dyspareunia and vulvodynia due to fibrosis and scarring of the introitus region. The main therapeutic measure in these cases is to treat the cause that triggers the vulvar fissure, and rule out concomitant pathologies, but despite this, standard treatments are usually insufficient to achieve healing and improvement.
Introduction: Vulvar fissures are linear erosions that characteristically occur in various areas of the vulva, most frequently in the posterior fourchette, mainly during vaginal intercourse. The use of regenerative therapies has been shown to improve the symptoms associated with vulvo -vaginal atrophy, and in patients with symptoms refractory to treatment, it presents a unique advantage, PRP injections act improving tissue regeneration through the secretion of several growth factors, leading to tissue proliferation and differentiation, neoangiogenesis and synthesis of new extracellular matrix.
Materials / method: A retrospective study was conducted, which included all patients treated with combination of autologous plasma rich in platelets and non-cross-linked hyaluronic acid ( Cellular Matrix/A-CP-HA Kit) in our center with a diagnosis of recurrent vulvar fissure, from January 2022 to January 2023. All patients receive one or two dose of treatment, the were also indicated treatment for underlying conditions, with corticosteroid cream or topical hormonal cream; Follow up until a year was performant.
Results: A total of 12 patients with recurrent vulvar fissure were included in this study, mean age of 53.5 years, of which 9 were in menopause, 4 of them had an early menopause, and 2 presented Vulvar lichen sclerosus, mean BMI 23.7. Two patients with aged of 34 and 24-year-old were diagnosticated with vulvar atrophy, the first as consequence of suppression of oral contraception and the second post chronic treatment with antifungal cream. No recurrences were reported in the first year after treatment. No side effects were reported, with recurrent of fissure in 4 patients after a year, all in menopause
Conclusion: The treatment of recurrent fissures must focus on their cause; any additional treatment must be complementary to an initial and continuous line of treatment, to prevent these complications from continuing to appear.They are not curative treatments; the triggering cause of the ulcer must be kept under control. In specific cases, a session of two doses separated by a month could be sufficient, but in patients with genitourinary syndrome of menopause , and with emphasis on patients with menopause early and lichen, continuous follow-up should be maintained, and the sessions offered to continue.
Declaraciones
¿Ha recibido algún tipo de financiamiento para realizar su investigación sobre esta temática?
No
¿Ha recibido algún pago, honorario u otra compensación por su trabajo acerca de esta investigación?
No
¿Tiene vínculos financieros con alguna entidad que podría llegar a competir estrechamente con los medicamentos, materiales o instrumentos tratados en su investigación?
No
¿Posee o ha solicitado una patente relacionada a los materiales, productos o instrumentos utilizados en su investigación?
No
Este trabajo no cuenta con el apoyo de ningún financiamiento directo o indirecto. El autor asume plena responsabilidad sobre el mismo.