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Objectives: To assess the clinical effectiveness of the combination therapy of intense pulsed light (IPL) and microneedling with a postbiotic lotion containing Lactobacillus fermentation lysate in facial melasma, with the objective of developing a comprehensive and effective treatment strategy for melasma.

Introduction: Intense pulsed light (IPL) alleviates skin pigmentation by the principle of selective photothermolysis. Lactobacillus fermentation lysate has the potential to repair the skin barrier and inhibit melanin production. Microneedling not only accelerates melanin metabolism and promotes skin self-repair but also enhances the transdermal absorption of therapeutic agents. However, the effectiveness and safety of the combination application of all three for melasma management remains to be fully elucidated.

Materials / method: Thirty participants were randomly divided into two groups. The IPL therapy group received IPL treatment (wavelength: 590-640 nm, pulse width: 3.0-4.0 ms, pulse delay: 40-50 ms, energy density: 14-18 J/cm2) at four-week intervals over a consecutive period of twelve weeks. The combination therapy group participated in a regime where IPL therapy and microneedling (needle length: 0.5 mm) were alternately carried out every two weeks throughout the 12-week treatment duration. The postbiotic lotion was applied immediately after the microneedling procedure.

Results: Compared to the baseline, both the IPL therapy group and the combination therapy group exhibited a significant reduction in the mMASI score, and the combination therapy group was more effective. The evidence of clinical photographic and VISIA-derived statistical data indicated that patients receiving the combined therapy experienced a decrease in facial speckle, a reduction in inflammation, and an improvement in hyperpigmentation, with over 73% of participants expressing very satisfied or satisfied. No significant adverse reactions were reported.

Conclusion: Our study demonstrated that combination therapy yielded significantly greater efficacy than IPL monotherapy. This combined treatment exhibited multiple synergistic benefits, including inflammation reduction, accelerated melanin metabolism, the restoration of skin microecological equilibrium and skin barrier enhancement. These advancements promoted postoperative skin recovery and reduced the incidence of adverse effects, presenting a promising therapeutic approach for individuals diagnosed with melasma.

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这项工作的完成感谢以下机构的支持： Guangzhou LTHINK Biotechnology Co. Ltd. (Guangdong, China); Guangzhou MLT Medical Cosmetic Clinic, Guangzhou, China.

Objectives: efficacy of Topical Timolol Drops in the Management of Pyogenic Granuloma of
Lip

Introduction: Pyogenic granuloma, also referred to as granuloma pyogenicum, is a prevalent, non-cancerous vascular tumor that develops in various tissues, including the skin and mucous membranes. The medically precise term for this condition is lobular capillary hemangioma. Treatment options include cauterization (either chemical or thermal), laser therapy, surgical excision, curettage, sclerotherapy, and cryotherapy. Additionally, topical timolol is gaining recognition as a non-invasive treatment option for pyogenic granulomas.

Materials / method: Individuals of both genders were enrolled in the study if they had pyogenic granuloma lesions that had been present for less than six weeks. A topical application of 0.5% timolol was administered thrice daily over a period of eight weeks. Evaluations were made regarding alterations in color, size, propensity to bleed, and any side effects experienced.

Results: All 10 patients demonstrated a full response within 8 weeks, and there was no recurrence observed during the 1-month follow-up. Additionally, none of the patients reported any local or systemic side effects.

Conclusion: Topical timolol administered as drops may be an effective, safe, and cost-efficient treatment for mucosal pyogenic granulomas. While topical timolol could be considered for early-stage pyogenic granulomas, further studies with extended durations are necessary to evaluate the rates of resolution and recurrence.

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Objectives: To Explore and integrate new and emerging technologies in scar management, such as stem cell therapy, PRP (Platelet-Rich Plasma), Chromatherapy, and innovative laser therapies and many more, to improve healing outcomes.

Introduction: Scars of whatever nature is aesthetically unsightly. It often presents a decrease of self-esteem to a person. Unfortunately, it is prevalent all over the globe. The Philippines is one of many countries with a scar-stricken population.

Nowadays, many options are available for the treatment of scarring, including chemical peeling, dermabrasion, laser treatment, punch techniques, fat transplantation, other tissue augmenting agents, needling, subcision, and many combined therapies. Various modalities have been used to treat scars, but limited efficacy and problematic side effects have restri

Materials / method: Power point presentation

Results: This lecture will tackle various types of scars from which it may be useful for selecting the best therapeutic strategy, whether it be single or combined therapy while reducing or avoiding the side effects and complications.

Delegates will learn innovative treatments in scar management

Conclusion: Ultimately, scar management is an ongoing process that requires a tailored, patient-centered approach. As new technologies and treatment options continue to emerge, there is immense potential to improve outcomes and offer hope for individuals seeking to minimize the impact of scars on their lives. Through comprehensive care, it is possible to achieve not only improved scar appearance but also enhanced quality of life for those affected.

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