Objectives: The field of aesthetic medicine has seen a significant evolution with the introduction of thread lifting techniques that address facial anti-ptosis. Current innovations have expanded the functionality of these threads from simply repositioning soft tissues to actively improving skin quality. This study examines the effectiveness of various thread compositions, particularly P(LA/CL)HA, in comparison to PDO, PGA, PLLA, and PCL, assessing their rheological behavior, dissolution times, and fixation abilities within the tissues.

Introduction: Our clinic has conducted a histological study on pigs over a six-month period to observe the in vivo effects of P(LA/CL)HA thread implantation. The pre-clinical study entailed detailed observations post-implantation, focusing on the inflammatory response, rehabilitation time, fibrotic tissue formation, and the stimulation of elastin and collagen types I and III.

Materials / method: Additionally, the study involved an extensive literature review and analysis of various threads, considering their absorption periods and tissue fixation capacities. The P(LA/CL)HA threads were noted for their extended absorption period of up to two years, offering a significant advantage in sustained tissue support compared to other threads that absorb in less than a year. The study also evaluated the fixation surface area provided by projections versus cones on the threads.

Results: Threads composed of P(LA/CL)HA showed a decreased inflammatory response, reduced rehabilitation time, and less fibrotic tissue formation. The histological studies confirmed enhanced stimulation of elastin and collagen types I and III. These findings are indicative of the threads' advanced biocompatibility and stimulation effect, contributing to an expedited recovery process and natural tissue integration, significantly impacting skin quality and structure.

Conclusion: Threads composed of P(LA/CL)HA showed a decreased inflammatory response, reduced rehabilitation time, and less fibrotic tissue formation. The histological studies confirmed enhanced stimulation of elastin and collagen types I and III. These findings are indicative of the threads' advanced biocompatibility and stimulation effect, contributing to an expedited recovery process and natural tissue integration, significantly impacting skin quality and structure.

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