Objectives: The aim of this study to compare the results of injections of platelet-rich plasma (PRP) and platelet-rich plasma (PRP) in combination with stromal vascular fraction (SVF), which is rich in adipose-derived stromal cells (with a potential in modulating hair growth cycle) in the upper scalp for the treatment of AGA.

Introduction: Androgenetic alopecia (AGA) or male pattern baldness is characterized by reduction of the hair follicles gradually causing conversion of terminal hairs into vellus hair, leading to progressive reduction of the density of hair on the scalp.

Materials / method: In this study, 220 adult patients presenting with male pattern baldness were included. Patients were divided into two groups. Group 1 containing 110 patients received plain Platelet-Rich-Plasma (prp) treatment, while the second group was treated with PRP in combination with exosomes. Over the course of the study, a total of 6 sessions were conducted, with each session spaced 4 weeks apart. The results were assessed at the baseline, after 4thsession, and 1 month after 6th session. Pre and post trichoscopy images were taken.
The assessment of outcomes included both re-injection and changes in ha

Results: Hair density was significantly increased after 6 weeks and 12 weeks post injection were seen with platelet-rich plasma (PRP) in combination with exosomes In hair-to-hair matching analyses, new hair grew from active follicles. Furthermore, nonfunctioning hair follicles filled with hyperkeratotic plugs, up to today assumed incapable of forming new hair, proved to grow new hair. No side effects were noted after treatment.

Conclusion: Intra dermal administration of platelet-rich plasma in combination with exosomes showed significant increase in hair density, improves hair regrowth within 6 to 12 weeks. Overall, exosomes hold promise in influencing the hair growth cycle and may serve as a potential therapy in AGA.

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