Objectives: This study aimed to evaluate the effectiveness of combining rose stem cell-derived exosomes (RSCEs) with the innovative 1064-nm fractional picosecond laser (FPL) technique for the treatment of androgenetic alopecia (AGA).

Introduction: Exosomes have been identified as key players in hair development and regeneration, offering promising therapeutic potential for alopecia. The 1064-nm FPL technology further complements this approach by stimulating hair growth effectively without damaging existing hair shafts.

Materials / method: In this pilot study, 10 male participants with mild-to-moderate AGA underwent five treatment sessions of 1064-nm FPL followed by topical application of RSCEs at four-week intervals. A follow-up evaluation was conducted four weeks after the final session. Treatment outcomes were assessed using expert panel evaluation scores, a seven-point patient satisfaction scale, and dermoscopic analysis for hair shaft and side effect monitoring.

Results: Clinical improvements were observed from the first to the sixth month post-treatment, with significant increases in expert panel scores. Patients reported noticeable enhancements in hair density and thickness as early as the first month. Side effects were minimal and temporary, with dermoscopic analysis showing minor petechiae and no damage to hair shafts.

Conclusion: The combination of 1064-nm FPL and RSCEs appears to be a promising and effective approach for promoting hair regrowth in male androgenetic alopecia. Further research is needed to refine and validate this treatment strategy for broader clinical application.

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