IMCAS

LABORE - From medical therapy to skin health: Unveiling the potent efficacy of NAD+ for brightening

Objectives: To assess the effectiveness of Nicotinamide Adenine Dinucleotide (NAD) as brightening agent

Introduction: Hyperpigmentation from UV-induced melanogenesis contributes to conditions like melasma, PIH, and uneven skin tone. Conventional brightening agents—such as niacinamide, cysteamine, alpha-arbutin, 2-mercaptonicotinoyl glycine, and isobutylamido thiazolyl resorcinol primarily inhibit tyrosinase or melanin intermediates, but often face limitations like irritation or instability. NAD⁺ (nicotinamide adenine dinucleotide), a key coenzyme in cellular energy and DNA repair, also activates sirtuins, PARPs, and redox enzymes—core regulators of oxidative stress, inflammation, and epigenetic balance. These

Materials / method: A randomized, single-blind study in 33 participants used a UV-induced melanization model on the back. Seven formulations were applied twice daily for 4 weeks: Placebo, 0.1% NAD+, 10% Niacinamide, 2.5% Encapsulated Cysteamine, 2% Alpha-Arbutin, Commercial serum with 2-MNG, Commercial serum with isobutylamido thiazolyl resorcinol. Assessments were conducted after 4 weeks on parameters: ITA° (Individual Typology Angle, CM26-dG), Melanin index (Mexameter® MX18), Visual grading by board-certified dermatologists

Results: All treatments showed statistically significant improvement over placebo (p < 0.05). ITA° gains were highest with NAD+ (+16.1%), followed by niacinamide (+13.5%), cysteamine (+13.3%), alpha-arbutin (+12.8%), Thiamidol (+11.7%), and 2-MNG (+9.3%) versus placebo (+11%). In melanin index reduction, niacinamide (-12.5) was strongest, followed by cysteamine (-11.9), isobutylamido thiazolyl resorcinol (-11.8), NAD+ (-11.6), alpha-arbutin (-11.0), and placebo (-10.6). For visual grading, alpha-arbutin (-20.4) and niacinamide (-18.5) showed the greatest clinical brightening, followed closely by NAD+ (

Conclusion: Topical 0.1% NAD+ demonstrated superior improvement in ITA° and comparable reductions in melanin index and clinical pigmentation versus benchmark actives. With its multi-pathway mechanism, excellent tolerability, and statistically validated efficacy, NAD+ emerges as a promising innovation in the treatment of hyperpigmentation and skin tone correction.

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Укажите дату....: Patent Pending
и статус: 28 May 2025

Эта работа представлена благодаря поддержке: LABORE

LEASEIR - Next generation hair removal: effective, safe and profitable

MOYOM BIOTECHNOLOGY - Elegant contour, dynamic regeneration - Clinical application of CaHA

PHARMARESEARCH CO., LTD. - Efficacy and safety of polynucleotides in multiple clinical studies

NOVOXEL - Tixel®: Precision meets performance in skin rejuvenation

Objectives: This presentation aims to explore the clinical benefits, mechanism of action, and treatment outcomes associated with Tixel®, a novel device utilizing Thermo-Mechanical Fractional Injury (TMFI) technology. The specific objectives are: (1) to highlight the anatomical relevance of the papillary dermis in facial rejuvenation; (2) to demonstrate how TMFI targets this layer to stimulate collagen remodeling and enhance skin quality; (3) to evaluate treatment outcomes through a retrospective clinical review; and (4) to discuss Tixel’s secondary role in transdermal drug delivery.

Introduction: The architecture of the skin is fundamental to facial aesthetics. Each anatomical layer plays a distinct role in maintaining the structural integrity and appearance of the skin. The papillary dermis is responsible for skin texture, firmness, and elasticity due to its rich population of fibroblasts and ECM components. As such, it serves as a key target in modern skin rejuvenation therapies. Tixel®, based on Thermo-Mechanical Fractional Injury (TMFI) technology, delivers controlled thermal energy via a heated titanium tip in a non-ablative manner.

Materials / method: A retrospective clinical analysis was performed on patients treated with Tixel® using TMFI technology for indications including skin aging, textural irregularities, and dermal laxity. Evaluation methods included standardized clinical photography, objective assessments of skin texture and elasticity, and validated patient-reported satisfaction surveys. Treatment protocols were assessed in conjunction with a review of literature, aiming to contextualize TMFI’s unique mechanism of action and its clinical value within the broader field of energy-based dermatologic devices.

Results: Treatment with Tixel showed consistent improvements in skin texture, elasticity, and radiance. Clinical photography and objective assessments confirmed visible smoothing of fine lines and enhanced dermal tone. Patient satisfaction was high, with minimal reports of discomfort or extended downtime. The outcomes aligned closely with published data, reinforcing TMFI’s efficacy in stimulating dermal remodeling through targeted thermal injury while preserving skin surface integrity.

Conclusion: Effective skin rejuvenation requires precise targeting of distinct anatomical layers using EBDs that harmonize with skin physiology. Tixel offers a scientifically grounded and clinically validated method for improving skin texture and elasticity. Its non-ablative nature ensures minimal recovery time, while its ability to enhance topical drug absorption broadens its therapeutic potential. Tixel exemplifies the convergence of precision and performance in aesthetic dermatology, providing reproducible outcomes with a high safety profile across varied skin types.

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Укажите, пожалуйста, лица (индивидуальное, предприятие, организация): NOVOXEL - KOL

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Укажите лица (физическое лицо, предприятие, ассоциация): NOVOXEL - KOL

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Эта работа представлена благодаря поддержке: NOVOXEL - KOL

UNILEVER - Skin barrier: Why the Microbiome matters?

Objectives: This study aims to discover the indispensable role of skin microbiome in skin barrier health and how topical products support their functions.

Introduction: Human skin is inhabited with commensal bacteria which play an indispensable role in multiple skin functions such as providing the first layer of barrier. In our study, we discovered a new mechanism in which Staphylococcus epidermidis, one of the most common skin commensals, utilizes glycerol as prebiotic to produce lactic acid.

Materials / method: The ability of S. epidermidis to metabolize glycerol in vitro and in vivo to lactic acid were measured. Additionally, the impact of the glycerol ferments on skin barrier markers, such as filaggrin (FLG) and acid sphingomyelin phosphodiesterase 1 (SMPD-1), was also investigated using 2D and 3D skin culture models. Alteration of barrier properties and microbiome composition in response to topical product application were also assessed in an in vivo study using volunteers with skin dryness.

Results: Our in vitro and in vivo experiments showed a dose-dependent increase in lactic acid levels upon application of increased concentrations of glycerol compared to the control. Using 2D and 3D skin culture models, we showed that the fermentation of glycerol, mainly lactic acid, upregulates the expression levels of key genes associated with skin barrier properties. Additionally, application of topical products containing glycerol supported increment of beneficial bacteria and concomitant improvements in skin barrier properties together with increased levels of ceramides and long-chain fatty acids.

Conclusion: Using a combination of in vitro, in vivo and analytical methods, we have shown that commensal bacteria are capable of fermenting glycerol to impart skin benefits such as improving the skin barrier properties.

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Эта работа не была поддержана никаким прямым или не прямым финансированием. Находится под собственной ответственностью автора.

CUREL - CUREL Ceramide Technology

Objectives: The ceramide technology is improving a great deal recently.

Introduction: We describe the technology of ceramide effects

Materials / method: ・The importance of Ceramide to Sensitive Skin

・Efficacy of Curél Deep Moisture Spray

Results: It is effective

Conclusion: ・The importance of Ceramide to Sensitive Skin

・Efficacy of Curél Deep Moisture Spray

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Укажите лица (физическое лицо, предприятие, ассоциация): Curel conpany

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Эта работа представлена благодаря поддержке: Curel

CUREL - CUREL Ceramide Technology

WIQO - Beyond injections. PRX plus: the needle free skin booster

IDENEL - Korean glass skin trends: Easy and safe ways to get skin glow

JINBO BIO - PHARMA - Accelerating skin regeneration with recombinant Collagen III in clinical practice

ENDYMED MEDICAL - 3-in-1 rejuvenation: Mini shaper, intensif, and skin booster

Objectives: To demonstrate the enhanced clinical outcomes achieved by combining Endymed’s 3DEEP® RF technology—via handpieces such as the Mini Shaper and Intensif—with injectable skin boosters for non-invasive facial contouring and skin rejuvenation.

Introduction: The aesthetic market is rapidly shifting toward integrative, minimally invasive procedures that provide natural-looking yet impactful results. A key emerging trend is the combination of energy-based devices with biostimulatory injectables to address both structural contouring and dermal quality. Endymed’s 3DEEP® patented radiofrequency technology offers controlled, deep dermal heating, which synergizes effectively with skin boosters to improve skin texture, elasticity, and definition, particularly in the face and jawline.

Materials / method: This session will present clinical protocols combining Endymed’s Mini Shaper and Intensif handpieces with skin booster injections in a staged or same-day approach. Key parameters such as treatment timing, energy settings, and anatomical targeting will be discussed, along with patient selection and safety considerations. Clinical cases will include protocols designed to enhance lower face definition, submental tightening, and skin density through dual-modality stimulation.

Results: Documented patient cases will show visible improvements in facial contouring, skin hydration, firmness, and glow. The synergistic effect of 3DEEP RF-induced collagen remodeling with dermal stimulation from skin boosters resulted in high patient satisfaction and optimal aesthetic enhancement.

Conclusion: The combination of Endymed’s 3DEEP® RF technology with injectable skin boosters represents a forward-thinking approach in aesthetic practice, aligning with current demands for non-surgical, personalized treatments. This integrative method offers practitioners a powerful tool to deliver enhanced and long-lasting facial rejuvenation results.

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Укажите лица (физическое лицо, предприятие, ассоциация): Endymed

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Эта работа представлена благодаря поддержке: Endymed

CELLENIS® DERMAFILLER - Cellenis PRP for hair loss: New developments in science, results, and best practices

ADVALIGHT - ADVATx laser in aesthetic dermatology: Combining 589 nm & 1319 nm for optimal Melasma and photo rejuvenation

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Укажите, пожалуйста, лица (индивидуальное, предприятие, организация): Advalight

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Укажите лица (физическое лицо, предприятие, ассоциация): Advalight

Есть ли у Вас финансовые отношения с лицами, тесно конкурирующими с препаратами, изделиями или приборами, указанными в вашей презентации?
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Эта работа не была поддержана никаким прямым или не прямым финансированием. Находится под собственной ответственностью автора.

HYUNDAE MEDITECH - Exosome where are we and how should we deliver them?

DFKBIOLAB INC. History and product presentation

SOFWAVE MEDICAL - Changing the paradigm : Treat to total energy, a volumetric analysis

ENDYMED MEDICAL - Periorbital rejuvenation with RF and combination treatments – Case studies

CELLENIS® DERMAFILLER - Cellenis DermaFiller – A natural filler and autologous biostimulator: applications and the science behind stimulation.

UNILEVER - An integrative approach to unlock brighter skin

Objectives: Our research aims to demonstrate the importance of the network pharmacology combined with multi-omics analysis in developing cosmeceuticals from natural sources.

Introduction: Increasing concern for skin disorders has resulted in high demand for the development of superior cosmetic products. TCM formulae (consisting of 2 or more medicinal herbs) has been used over thousands of years for maintaining healthy aging, beauty and wellbeing in China. Therefore, it’s critical to discover its scientific significances of synergistic effects and underlying mechanisms from perspective of systems biology.

Materials / method: Using San Bai Decoction as a case study, network pharmacology analysis was conducted to map out the compound and target interaction network were visualized using Cytoscape; cheminformatics analysis was performed on LC-MS/MS. A double-blind, placebo-controlled clinical trial was conducted to evaluate the efficacy of USBT2627 in alleviating UV-induced skin damage and explore the underlying mechanism using a differential network analysis of transcriptomic data approach. Transcriptomics study was conducted in three in vitro models separately for the identification of differentially expressed genes

Results: The chemical profiling finally identified more than 72 chemicals with absolute content contained by USBT2627 and prioritized 22 lead actives in USBT2627 for future exploration. Formula containing USBT2627 significantly reduced UV-induced skin pigmentation compared to the placebo group and effectively mitigated erythema. The transcriptomic analysis, which combines conventional differential expression with differential network analysis, indicated that USBT2627 regulated multiple pathways related to skin pigmentation, such as ET1 signaling and pigmentation signaling pathways.

Conclusion: Together, USBT2627 suppresses melanin accumulation and protects skin against UVB exposure through not only directly targeting melanogenesis but also through multiple pathways. Those findings were consistent with the network pharmacology prediction, also provide solid evidence and novel insights for supporting USBT2627 as a novel skin brightening agent.

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Эта работа представлена благодаря поддержке: UNILEVER

SPECLIPSE, INC. - Beyond pigment removal : The next generation of Picosecond laser in skin rejuvenation

Objectives: Picosecond lasers, beyond their primary use in tattoo removal and hyperpigmentary conditions, are increasingly used in aesthetic practice like scarring, rhytides, and tissue remodeling. This versatile technology can break down pigment particles and stimulate collagen production, offering a range of cosmetic and medical applications.

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Укажите, пожалуйста, лица (индивидуальное, предприятие, организация): Beauty solution

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Укажите лица (физическое лицо, предприятие, ассоциация): Beauty solution

Есть ли у Вас финансовые отношения с лицами, тесно конкурирующими с препаратами, изделиями или приборами, указанными в вашей презентации?
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Эта работа представлена благодаря поддержке: I recieve the Honoraria from Beauty Solution.

IDENEL - Innovative topical Collagen booster : Peptaxel™

BIOHA LABORATORIES - Novion SLT (selective light system)

Objectives: To present a novel clinical approach to skin rejuvenation using photobiomodulation through Novion, a non-invasive near-infrared light-based system. The goal is to demonstrate that cellular and tissue-level regeneration can be triggered without causing thermal injury, pain, or downtime. This approach targets mitochondrial activation and biochemical signaling, aiming to shift the paradigm from destructive laser-based resurfacing to biologically guided rejuvenation. The objective also includes identifying how specific wavelengths and continuous thermal emission can influence fibroblast function,

Introduction: Traditional energy-based devices rely on selective photothermolysis—deliberately damaging tissue to stimulate repair. However, this can cause pain, downtime, and potential complications. Photobiomodulation (PBM) offers a fundamentally different concept: using light as a biological signal rather than a destructive force. Novion introduces plasma-based incoherent NIR light filtered to 1064nm, which penetrates deeply and safely. By stimulating cytochrome c oxidase within mitochondria, Novion enhances ATP production, nitric oxide release, and calcium influx. This cascade initiates regeneration wit

Materials / method: Novion emits filtered continuous-wave near-infrared light (≥1064nm) using a plasma-derived incoherent light source. The system includes a sapphire cooling tip to protect the epidermis while allowing heat to accumulate in the dermis (45–60°C). Treatments target areas with loss of volume, elasticity, or tone. The photonic energy is absorbed by cytochrome c oxidase, triggering mitochondrial activation and downstream signaling. Additionally, calcium channels are stimulated, leading to expression of growth factors, cytokines, and HSPs. The method is applied in outpatient settings with no anesthesia

Results: Clinical observations show improved skin tone, texture, elasticity, and pore reduction after a series of Novion treatments. Histologically, fibroblasts appear more active with enhanced collagen and elastin deposition. Patient feedback reports high satisfaction, particularly due to the absence of pain or recovery time. Real-time imaging and infrared thermography confirm deep, controlled dermal heating without epidermal damage. Notably, improvements are progressive, indicating cumulative biological effects. Cases also demonstrated reduction in inflammation markers and signs of vascular remodelin

Conclusion: Novion demonstrates that photobiomodulation, when delivered precisely through continuous NIR light, can activate the skin’s regenerative mechanisms without injury. By stimulating mitochondria and initiating intracellular signaling, tissue can be remodeled safely, comfortably, and repeatedly. This challenges the conventional laser-based model of "destroy to renew," offering instead a "stimulate to restore" philosophy. Novion represents a new class of skin energy systems that combine biology and physics to achieve visible, long-term rejuvenation with minimal risk and maximal compliance.

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Укажите, пожалуйста, лица (индивидуальное, предприятие, организация): yumeco

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Эта работа представлена благодаря поддержке: Mr. Mark

REGEN BIOTECH, INC - From hollow to harmony: The role of PDLLA in the Ozempic aesthetic

KENVUE - DR.CI:LABO- Expert insights and clinical evaluation of 377 Radiance Serum (Phenylethyl Resorcinol) as adjunct to aesthetic treatment

KENVUE - DR.CI:LABO – Mitigating early signs of skin aging: A closer look at VC100 (APPS), a novel vitamin C derivative, and its synergistic effects with aesthetic treatment

KORU PHARMA - Achieving a naturally glowing complexion with Mesoheal Pink Glow

BLUECORE COMPANY - Study of New Fractional (Recurve) rejuvenation treatment with a Pico Second Laser

JSK BIOMED INC - Mirajet: New horizon in body scar treatment

CLINICEO - Turning practitioners into CEOs: Streamline your clinic operations, gain complete control, and focus on what matters most—patient satisfaction. Leave the rest to Cliniceo.

Время	Спикеры	Заголовок сессии	Абстракт	Номер
09:15	Anita FAJRIN	LABORE - From medical therapy to skin health: Unveiling the potent efficacy of NAD+ for brightening	Посмотреть	146598
09:30	Francisco MARTINEZ	LEASEIR - Next generation hair removal: effective, safe and profitable		146599
09:45	Fei CHEN	MOYOM BIOTECHNOLOGY - Elegant contour, dynamic regeneration - Clinical application of CaHA		146600
10:00	Доктор Polen TE	PHARMARESEARCH CO., LTD. - Efficacy and safety of polynucleotides in multiple clinical studies		146601
10:15	Доктор Guy ERLICH	NOVOXEL - Tixel®: Precision meets performance in skin rejuvenation	Посмотреть	146607
10:30	Li Oon CHUAH	UNILEVER - Skin barrier: Why the Microbiome matters?	Посмотреть	146602
10:45	Доктор Paisal RUMMANEETHORN	CUREL - CUREL Ceramide Technology	Посмотреть	146603
11:00	Sopit YONGYUT	CUREL - CUREL Ceramide Technology		149164
11:30	Доктор Deborah SUBISSATI	WIQO - Beyond injections. PRX plus: the needle free skin booster		146605
11:45	Доктор Hosung CHOI	IDENEL - Korean glass skin trends: Easy and safe ways to get skin glow		146606
12:00	Доктор James Yui LAM	JINBO BIO - PHARMA - Accelerating skin regeneration with recombinant Collagen III in clinical practice		146608
12:15	Доктор Jed YEOW TEO	ENDYMED MEDICAL - 3-in-1 rejuvenation: Mini shaper, intensif, and skin booster	Посмотреть	146609
12:30	Доктор Lehavit AKERMAN	CELLENIS® DERMAFILLER - Cellenis PRP for hair loss: New developments in science, results, and best practices		146604
12:45	Доктор Jacqueline LUNA	ADVALIGHT - ADVATx laser in aesthetic dermatology: Combining 589 nm & 1319 nm for optimal Melasma and photo rejuvenation		146611
13:00	Доктор Kyuho YI	HYUNDAE MEDITECH - Exosome where are we and how should we deliver them?		148282
13:15	Carolina SUNG	DFKBIOLAB INC. History and product presentation		148281
13:30	James BARTHOLOMEUSZ	SOFWAVE MEDICAL - Changing the paradigm : Treat to total energy, a volumetric analysis		146612
13:45	Доктор Abhay TALATHI	ENDYMED MEDICAL - Periorbital rejuvenation with RF and combination treatments – Case studies		148283
14:00	Доктор Lehavit AKERMAN	CELLENIS® DERMAFILLER - Cellenis DermaFiller – A natural filler and autologous biostimulator: applications and the science behind stimulation.		146613
14:15	Xuelan GU	UNILEVER - An integrative approach to unlock brighter skin	Посмотреть	146614
14:30	Доктор Vasanop VACHIRAMON	SPECLIPSE, INC. - Beyond pigment removal : The next generation of Picosecond laser in skin rejuvenation	Посмотреть	146615
14:45	Prof Noura LEBBAR	IDENEL - Innovative topical Collagen booster : Peptaxel™		146616
15:00	Доктор Gong Chan RAH	BIOHA LABORATORIES - Novion SLT (selective light system)	Посмотреть	146617
15:15	Доктор Lehavit AKERMAN	REGEN BIOTECH, INC - From hollow to harmony: The role of PDLLA in the Ozempic aesthetic		146618
15:30	Prof Li LI	KENVUE - DR.CI:LABO- Expert insights and clinical evaluation of 377 Radiance Serum (Phenylethyl Resorcinol) as adjunct to aesthetic treatment		146619
15:45	Доктор Arata TOMORI	KENVUE - DR.CI:LABO – Mitigating early signs of skin aging: A closer look at VC100 (APPS), a novel vitamin C derivative, and its synergistic effects with aesthetic treatment		146620
16:00		Coffee break		146621
16:30	Доктор Jaehyun CHEON	KORU PHARMA - Achieving a naturally glowing complexion with Mesoheal Pink Glow		146622
16:45	Ho Woong CHOI	BLUECORE COMPANY - Study of New Fractional (Recurve) rejuvenation treatment with a Pico Second Laser		146623
17:00	Доктор Juhyuk PARK	JSK BIOMED INC - Mirajet: New horizon in body scar treatment		146624
17:15	Доктор Mary June CADIGAL	CLINICEO - Turning practitioners into CEOs: Streamline your clinic operations, gain complete control, and focus on what matters most—patient satisfaction. Leave the rest to Cliniceo.		146625

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