IMCAS

Innovative Skin Aging Solutions: The Synergistic Effects of PRP and PRF with BAP Injection Technique

Objectives: We observed significant improvements in pigmentation and pore size compared to baseline. Additionally, there were noticeable improvements in nasolabial folds, marionette lines, and acne scars post-treatment. The highest levels of improvement were observed at week 4, followed by a gradual decrease over time. No serious adverse effects were reported, apart from mild procedural pain (3.5/10 on the pain scale) and transient redness that resolved within 1–2 days.

Introduction: Platelet-Rich Plasma (PRP) has long been recognized as one of the leading solutions for addressing skin aging concerns. Numerous studies have highlighted the exceptional role of PRP in treating wrinkles, enlarged pores, skin hydration, and hair loss. In recent years, Platelet-Rich Fibrin (PRF) has emerged as a promising new agent. However, research on the combined use of PRP and PRF remains limited, and the techniques for utilizing PRF in aesthetic dermatology have not been fully elucidated. Therefore, this study was conducted to explore these areas further.

Materials / method: We conducted a study involving 10 patients who underwent a combination of PRP and PRF treatments using the BAP injection technique specifically for the facial area. Patients were assessed using VISIA imaging at baseline (prior to treatment) and at 2 weeks, 4 weeks, 8 weeks, and 12 weeks post-treatment. Eight parameters were evaluated through VISIA, including spot, UV spot, brown spot, wrinkles, redness, porphyrins, texture, and pores. Additionally, we assessed the improvement in forehead wrinkles, crow’s feet, cheek wrinkles, nasolabial folds, marionette lines, and acne scars.

Results: The brown spots index had a mean baseline value of 68.4% (n=10), peaked at 77.2% (n=10) at week 4, and gradually decreased to 67.9% (n=10) at week 8 and 64.14% (n=7) at week 12. Similarly, the pore index showed a mean baseline value of 30.3% (n=10), steadily increasing to 37.4% (n=10) at both week 4 and week 8, before declining to 32.57% (n=7) at week 12. The highest levels of improvement were observed at week 4, followed by a gradual decrease over time. No serious adverse effects were reported, apart from mild procedural pain (3.5/10) and transient redness that resolved within 1-2 days

Conclusion: The combination of PRP and PRF shows promising potential in improving skin surface conditions, including pigmentation, enlarged pores, and acne scars, as well as addressing other signs of skin aging such as nasolabial folds and marionette lines. The BAP injection technique is a suitable approach for PRF due to its simplicity, minimal pain, and quick application, which prevents PRF from transitioning into a solid state. Further studies are needed to validate the efficacy of the PRP-PRF combination and to optimize PRF injection techniques in aesthetic dermatology.

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Facial Gold Reinforcement: 28 Years of Experience in the Use of Gold Threads

Objectives: Facial Gold Reinforcement: 28 Years of Experience in the Use of Gold Threads

Objectives:

To present clinical outcomes from over 11,000 gold thread interventions performed over 28 years.

To outline patient selection, technique, and optimal anatomical layer for lasting results.

To assess patient satisfaction and complication rates using the Patient Satisfaction Scale (PSS).

To review histological evidence of collagen stimulation, angiogenesis, and skin improvement.

To confirm the compatibility of gold threads with future aesthetic interventions.

Introduction: Gold threads gained popularity in aesthetic surgery in the early 1990s. Manufactured in Spain, they consist of a 5/0 thread made of 99.99% pure gold (0.1 mm in diameter) combined with a polyglycolic component. Since their introduction, ongoing debate has surrounded their effectiveness. This study focuses on evaluating their clinical value based on long-term experience.

Materials / method: Gold thread implantation was performed on 11,062 patients over 28 years in four Moscow clinics. This retrospective study analyzed pre- and post-procedure photo collages and patient satisfaction using the Patient Satisfaction Scale (PSS). A detailed evaluation was conducted on 492 facial cases from 1996 to 2024. Among them, 86% were women aged 30–60, 11% women aged 20–30, and 3% men aged 25–60.

Results: One year after implantation, the Patient Satisfaction Scale (PSS) indicated a 91% success rate with minimal complications. Satisfaction scores were 4.8 after one month, 4.7 after six months, and 4.6 after one year, confirming stable long-term outcomes.

Conclusion: Gold thread implantation reinforces connective tissue, enhances skin hydration and elasticity, and provides a long-term rejuvenating effect. It does not interfere with future surgical or non-surgical aesthetic interventions, making it a safe and compatible technique in facial rejuvenation.

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Risk Factor Analysis for Vascular Occlusions after Dermal Filler Injections: A systematic review and meta-analysis

Objectives: This systematic review and meta-analysis aimed to identify, quantify, and analyse the key risk factors contributing to vascular occlusions following dermal filler injections and to propose a clinical

Introduction: Dermal fillers have become a cornerstone of minimally invasive facial rejuvenation. While generally safe, one of the most feared complications is vascular occlusion, which can result in tissue necrosis, vision loss, or permanent disfigurement. The underlying risk factors for such events are not fully elucidated, with much of the existing evidence derived from isolated case reports or small series.

Materials / method: A comprehensive literature search was conducted across PubMed, Embase, and the Cochrane Library to identify relevant case-control studies, cohort studies, and detailed case series reporting confirmed cases of vascular occlusion after dermal filler injections. Data were extracted on patient demographics, filler type, injection site, vascular anatomy involved, onset of symptoms, and treatment outcomes. Quality assessment was performed using the Joanna Briggs Institute checklist. Pooled odds ratios and significance testing (Fisher’s exact test) were calculated to assess associations between varia

Results: Fourteen studies met the inclusion criteria, comprising 31 unique patient cases. The mean age of affected patients was 42.6 years, and 71% were female. Hyaluronic acid (HA) was the most commonly used filler (61.3%). High-risk anatomical regions—particularly the glabella, nose, and nasolabial folds—were frequently implicated in occlusions. Involvement of major vessels such as the ophthalmic artery was significantly associated with poorer outcomes (OR 9.67, p=0.02), whereas occlusions involving smaller vessels like the supratrochlear or infraorbital branches were associated with better recovery.

Conclusion: Vascular occlusion following dermal filler injection is a multifactorial complication influenced by filler type, anatomical site, vascular anatomy, and treatment timing. This study presents a practical morbidity-risk stratification tool to aid in pre-procedure planning and patient counselling. Early recognition and intervention, particularly with hyaluronidase in HA-related events, remain critical for minimizing morbidity. However, due to the reliance on retrospective data and case reports, further prospective, large-scale studies are necessary to validate these findings and establish standard

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A Structured Hair Filler Protocol for Optimal Hair Restoration Outcomes

Objectives: The primary objective of this study is to develop and evaluate a structured hair filler protocol that standardizes treatment approaches, enhances client outcomes, and ensures consistent, client-centered care in non-surgical hair restoration.

Introduction: Hair loss is a prevalent condition with significant psychosocial and aesthetic consequences, driving demand for effective non-surgical interventions. Hair filler therapy has emerged as a promising treatment modality; however, the absence of standardized protocols may contribute to variable outcomes and suboptimal patient satisfaction. This study introduces a structured hair filler protocol designed to optimize treatment efficacy, improve patient adherence, and ensure consistent, evidence-based care in non-surgical hair restoration.

Materials / method: A structured hair filler protocol was developed to standardize treatment and optimize patient outcomes. Each patient underwent a comprehensive consultation, during which the severity of hair thinning was assessed and classified into one of four categories:
Type 1: Mild hair thinning with slightly increased shedding, typically requiring three sessions.
Type 2: Moderate thinning with mild scalp visibility.
Type 3: Significant hair weakening with pronounced scalp visibility, growth stagnation, and the presence of vellus hair, typically requiring six to eight sessions.
Type 4: Long-standing ba

Results: Implementation of the structured protocol demonstrated improved patient-reported satisfaction and clinical outcomes. Optimal hair restoration effects were typically observed after four months, with significant improvements by the fourth session. The incorporation of adjuvant serum therapy extended maintenance intervals, reducing the frequency of required follow-up sessions. Standardized photographic tracking improved patient engagement and adherence to the treatment plan.

Conclusion: This structured hair filler protocol provides a systematic and evidence-based framework for non-surgical hair restoration. By standardizing treatment regimens, optimizing maintenance schedules, and integrating adjunctive pharmacotherapy, the protocol enhances clinical efficacy and improves patient-centered outcomes. These findings contribute to advancing non-surgical hair restoration methodologies and promoting optimal outcomes in aesthetic medicine.

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Эта работа представлена благодаря поддержке: Sarasin Clinic Belgium

Neck Rejuvenation with a Combination of PDLLA, HIFU & Botulinum Toxin A.

Objectives: The aim of the study is to evaluate the efficacy of a combination protocol with High-Intensity Focused Ultrasound (HIFU), Poly-D,L-lactic acid (PDLLA) and botulinum toxin A in mild to moderate neck skin aging. Neck skin aging, involves horizontal lines, prominent platysmal bands, sagging skin, fine lines, loss of jawline definition and is a challenging problem, as patients’ satisfaction rates are relatively low when a monotherapy is applied.

Introduction: Botulinum toxin A is the gold standard for platysmal bands and vertical bands of the neck. HIFU, through thermal damage, leads to collagen production, skin tightening and rejuvenation, targeting to deep dermis and SMAS. PDLLA is a biocompatible collagen biostimulator that promotes neocolagenesis, enhances elasticity, and promotes skin rejuvenation and gradual skin tightening.
In the present study, we examine the effectiveness of combining BTX-A with PDLLA and HIFU as a way to address stubborn signs of neck aging.

Materials / method: 89 patients (69 women, 20 men; mean age:53y) with moderate neck aging were enrolled in the study. All patients had undergone BΤΧ-Α in the past as monotherapy.
The protocol consisted of BTX-A administered on day 1 (average:41u in platysmal bands & 25u in jawline -Nefertiti lift).
HIFU was performed on day 14, 35 and 56 after BTX-A, targeting depths of 3 and 4,5 mm (mean shots: 350 per session).
PDLLA injected by cannula in average dose of 3ml per neck side, diluted in 10ml SWFI per vial, followed on day 28, 49 and 70 after BTX-A. Photographs were taken on day 1 & 2 months after the last PDLL.

Results: A significant reduction in vertical neck bands and neck skin texture was observed 15 days after the completion of treatments, with a patient satisfaction rate of 89% on month 4, way higher than botulinum toxin A monotherapy (55%).
Patients reported improvement in both dynamic and static wrinkles, skin elasticity and thickness, sagging, overall texture and firmness.
Nearly all patients reported improved skin tone, hydration, and jawline definition, with no severe side effects observed, apart from mild erythema and slight bruising after HIFU and PDLLA.

Conclusion: The combination of BTX-A, HIFU and PDLLA is a safe minimally invasive therapeutic approach with excellent results in treating neck skin aging.
The combined protocol targeted all structures of neck and lower face that contribute to skin aging. In addition, BTX-A seems to have a better performance and longer duration when applied as a part of an EBD and PDLLA potocol.

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Evaluation of the efficacy and safety of combination with oral tranexamic acid, cysteamin and polynucleotide injection for melasma.

Objectives: Melasma is a common melanin disorder in vietnamese women. Various approaches still show limitations. Polynucleotide, known as bio-regenerative injection could play the role in hypopigmenting properties.

Introduction: To compare the efficacy and safety of combination with oral tranexamic acid, topical cysteamin 7.5% and polynucleotide (PN) injection in the treatment of melasma

Materials / method: 60 female patients of facial melasma were divided in to 3 groups. Group A (20 patients) was only injected 20mg polynucleotide (PN) for 3 times every 2 months. Group B (20 patients) were described oral 500mg tranexamic acid per day, applied cysteamin 7.5% cream every day. Group C (20 patients) was asked to take the same oral pills, skincare routine and injected PN solution for 3 times within 6 months. We recorded digital potograghs, modified melasma area severity index (mMASI), redness, patients satisfaction and downtime for evaluating.

Results: All groups showed significant changes in modified melasma area and severity index (mMASI) score after using the treatment (P<0.05). However, group C showed the highest improvement (>75%) in mMASI as compared to group B (60%) and group A (30%) after 6 months. There was 4 patients (20%) in group B complained abour irritation due to topical cysteamin 7.5% meanwhile there was no report in group C. There is down time from 24-48h in injected group and lowest satisfaction in group A

Conclusion: Oral TXA, topical cysteamin 7.5% was effective in melasma treatment. However, the decreasing of irritation rate and increasing of brightening effect was mentioned with polynucleotide injection.

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Current Status and Perception of Biostimulators in China: A Cross-Sectional Study on Medical Professionals and Patients

Objectives: To assess the current application and perceptions of biostimulators among medical professionals and patients in China, providing data to guide clinical practice.

Introduction: Aging embodies humanity’s profound sorrow, while beauty remains an eternal pursuit. ISAPS data reports 34.9 million aesthetic procedures in 2023, with non-surgical treatments growing 5.5% faster than surgical ones. Biostimulators, stimulating extracellular matrix regeneration, are emerging as alternatives to collagen/hyaluronic acid fillers, yet lack extensive clinical data in China since the first biostimulator was approved in 2021. Injectable practitioners require deeper material insights to optimize safe, effective applications.

Materials / method: A cross-sectional study employing convenience sampling was conducted. Questionnaires were distributed to aesthetic medical professionals and patients with biostimulator experience. Physician surveys (53 items, including single-choice, multiple-choice, ranking, and open-ended questions) were collected offline between November 2024 (n=125). Patient surveys (11 items) were simultaneously administered offline (n=232). Descriptive statistics were analyzed using SPSS 22.0, with absolute numbers and percentages (%) reported. The ranking questions were analyzed using the reverse scoring method.

Results: Biostimulators were widely applied for natural aesthetic outcomes (physicians: 84.0%; patients: 67.67%), particularly in facial treatments (score: 369). Gender-specific preferences were observed, with males prioritizing contour definition and females favoring tightness and lifting. However, 40.0% of physicians expressed dissatisfaction with product longevity, while 39.2% desired enhanced efficacy. Additionally, 19.2%, 43.2%, and 14.4% of physicians reported dissatisfaction with pre-mixing protocols, storage stability, and post-injection massage techniques, respectively.

Conclusion: Biostimulators are increasingly utilized for their natural aesthetic outcomes, though safety remains the primary concern. Comprehensive preclinical data and reliable clinical evidence are critical for product selection. We advocate for collaborative efforts among manufacturers, frontline clinicians, and basic research professionals to develop detailed clinical guidelines and standardized training programs, thereby improving satisfaction among healthcare providers and patients alike.

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Hybrid technique - calcium hydroxyapatite + hyaluronic acid. Instead of or together? How to achieve lifting and avoid overfill syndrome

Objectives: Since the boom in fillers, cosmetologists have tried to solve many problems with their help: to restore volumes, to achieve lifting, to reduce wrinkles and much more. As a result, we came to the conclusion that many patients look "bloated", which is called overfill syndrome. But it is impossible to achieve lifting with the help of hyaluronic acid preparations. With their help, we restore the lost volumes. And for lifting into the lateral areas of the face, we use calcium hydroxyapatite.

Introduction: Mauricio De Matzo divided the face into lifting and volumetric parts. And this is anatomically justified. And in order to obtain aesthetic results while preserving individual facial features, it is necessary to inject drugs into the lifting zones that reduce excess skin, this is calcium hydroxyapatite. And in volumetric zones, use hyaluronic acid preparations.

Materials / method: I use calcium hydroxyapatite in two types, in dilution with physical solution and in pure form, as well as hyaluronic acid in one procedure in different areas of the face, and I will share detailed video injection techniques and the results of 10 years of using this technique.

Results: In the report, I will present a video demonstration of a hybrid rejuvenation technique with calcium hydroxyapatite and hyaluronic acid preparations in different areas of the face in one procedure. The preparation of calcium hydroxyapatite in dilution with saline solution to reduce excess skin, pure hydroxyapatite for camouflage of malar fat packages, and deep injections of hyaluronic acid with high g prime in the central areas of the face to restore insufficient volume.

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Combination of Microneedling and Microbotox for Comprehensive Facial Rejuvenation: A Case Series

Objectives: To evaluate the clinical efficacy and safety of a combined treatment protocol of microneedling and Microbotox for improving skin texture, pore size, fine wrinkles, sebum control, and overall facial rejuvenation.

Introduction: Microneedling and microbotulinum toxin A (Microbotox) are established modalities for skin rejuvenation. However, the synergistic effect of combining these techniques has not been widely explored. This case series evaluates the efficacy and safety of combining microneedling with Microbotox in achieving comprehensive skin rejuvenation.

Materials / method: Ten female patients with Fitzpatrick skin types III–IV, aged 20–40, underwent a single session combining microneedling (needle depth 1.5 mm) with Microbotox mesotherapy. A total of 40 units of BoNT-A diluted in 3 mL hyaluronic acid were administered via intradermal microinjections to the full face immediately following microneedling. Patients were evaluated clinically and photographically at baseline, 1 month, and 3 months post-treatment. Outcomes assessed included skin texture, pore size, fine wrinkles, facial muscle tone, sebum control, and overall skin appearance. Both physician and patient

Results: All patients reported subjective improvement in skin texture, reduced pore size, and fine wrinkles. Objective photographic comparisons corroborated these findings. Sebum control and smoother skin surface were noted clinically in 90% of cases. One patient experienced mild facial stiffness while smiling, which resolved within one month. Overall, 100% of patients expressed satisfaction with treatment outcomes.

Conclusion: The combination of microneedling and Microbotox is a promising, minimally invasive approach for global facial rejuvenation. This technique provides enhanced skin texture, pore refinement, and wrinkle reduction with high patient satisfaction and minimal downtime. Further controlled studies are warranted to confirm these preliminary findings.

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Achieving Tissue Transposition Without the Excision of Additional Skin Folds in Minimally Invasive Forehead and Facelift Procedures

Objectives: The primary objective of this initiative is to introduce new minimally invasive procedures within the realms of authentic medicine and surgery

Introduction: The escalating demand for minimally invasive aesthetic procedures has catalyzed the advancement of innovative techniques that yield rejuvenating outcomes without necessitating extensive surgical interventions. This study presents a novel methodology for the transposition and fixation of tissues that avoids additional skin excision during Noninvasive forehead and facelift procedures. This technique employs endoscopic and US guidance to facilitate precise tissue dissection and manipulation

Materials / method: A prospective study was conducted involving 711 female patients and 47 male patients, aged 24 to 74 years, who underwent Minimally invasive forehead and facelift surgeries between January 2017 and March 2025. The procedures involved the transposition of forehead and facial tissues towards the temporal and occipital areas, executed without traditional skin excision. Temporal lines were employed for tissue fixation, thus eliminating the need for fixation devices such as screws or Endotines. Endoscopic and US visualization techniques were utilized to ensure precise tissue repositioning

Results: A total 758 patients underwent a Minimally-invasive forehead and facelift procedure, with no major complications reported. The evaluation of patient satisfaction was based on post-operative consultations, facial dimension measurements, and pre- and post-operative photographs for determining the level of satisfaction with the aesthetic outcomes.
The results demonstrated reduction in wrinkles, elevation of sagging tissues, and overall rejuvenation. 82% reported high levels of satisfaction and 15% of patients reported moderate improvement.

Conclusion: The transposition of tissues without the excision of excess skin, as well as the elimination of screws, Endotines, and other devices for tissue fixation under endoscopic and ultrasound guidance, represents a promising advancement in the field of Minimally-invasive facial rejuvenation. This technique facilitates the precise repositioning of tissues, yielding natural and youthful results while avoiding the scarring typically associated with conventional skin resection procedures. Furthermore, the reduced invasiveness and shorter recovery times associated with this approach

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A comparative study of hair reduction utilising a DIODE laser and an Nd: YAG laser in the Asian population.

Objectives: Diode and Nd: YAG lasers are used for hirsutism in Asian populations to achieve long-term hair reduction by targeting and damaging hair follicles. Diode lasers are effective for darker, thicker hair, while Nd: YAG lasers are suitable for various skin types, including darker skin tones, and penetrate deeper into the skin. The objective was to evaluate the efficacy and safety of the DIODE and long-pulse Nd: YAG laser on Asian Type IV-V skin.

Introduction: Facial hirsutism and hypertrichosis are common problems, and dermatology offers several methods for unwanted hair in many patients. The theory of selective photo thermolysis, a safe and effective method when operated by trained and experienced professionals, has revolutionised hair reduction. Before starting laser therapy, assessing the skin type, the fluence, the pulse duration, and the type of laser to be used is crucial for safety and outcome.

Materials / method: Seventy-five patients completed their treatment course with DIODE and long-pulsed Nd: YAG (1064 nm) with fluences between 16 J/cm2 and 20 J/cm2. The average hair density reduction was assessed using hair count on digital photographs at 1, 3, 6 and 9 months. Efficacy of hair reduction was graded according to a 4point visual scale from poor to excellent — poor < 25% reduction in hair from baseline; fair < 25–50% reduction in hair from baseline, good < 50–75% reduction in hair from baseline; and excellent > 75% reduction in hair from baseline.

Results: Six sittings of the Diode laser were done in all subjects within six months. At the third follow-up visit, the percentage of hair reduction was fair in 5.4% of patients, excellent in 73% of patients in group A and fair in 5.3%, excellent in 68.4% of patients in group A. In contrast, at the final follow-up visit, it was excellent in 81.1% of patients in group A and 50% in group B. P-value was significant (P 0.026). Erythema was observed to be the most common complication in both lasers, 32.4% and 26.3% of cases. The diode laser showed more efficacy and was more comfortable than the Nd: YAG las

Conclusion: For Asian skin with dark hair, the diode laser remains the preferred choice. However, it's important to note that the diode laser has a narrow margin of safety. Proper pre- and post-procedure cooling is crucial to minimise complications. Despite the diode laser's higher efficacy, it's worth considering that the side effects of the Nd: YAG laser are less in darker skin, making it a viable alternative.

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Visual Diagnosis and Aesthetic Restoration of the Generalized "Facial Over-filling Syndrome"

Objectives: This study is dedicated to constructing a precise visual diagnosis system for the generalized "facial over-filling syndrome". Through the integration and analysis of multi-dimensional data, it aims to achieve the rapid identification and classification of different symptoms. Meanwhile, personalized aesthetic restoration plans will be formulated to improve the patients' facial morphology and functions, provide standardized diagnostic and treatment norms for the medical aesthetics industry, and promote the healthy and sustainable development of the industry.

Introduction: Facial filling techniques have gained wide popularity due to their effectiveness in improving facial contours. However, the "facial over-filling syndrome" caused by over-filling has become increasingly prominent. It manifests as facial swelling, stiff expressions, abnormal proportions of facial features, etc., which not only affect aesthetics but may also pose potential health risks. Due to the lack of unified diagnostic criteria and effective restoration plans, it has severely restricted the development of the medical aesthetics industry.

Materials / method: Clinical cases of patients of different ages, genders, and regions are collected. High-frequency ultrasound and multi-angle photography are used to obtain facial data. Based on the diagnostic results, personalized restoration plans combining non-surgical methods and surgical methods (such as removal of filling materials and thread lift repair) are adopted, and the effects are evaluated through long-term follow-up.

Results: The visual diagnosis system has been successfully constructed, with a diagnostic accuracy rate exceeding 90%. The personalized restoration plans have significantly improved the facial appearance of 90% of the patients, restored their functions well, and achieved a satisfaction rate of over 90%, with stable long-term effects.

Conclusion: The diagnostic and restoration system established in this study is scientific and effective, providing a reliable basis for clinical practice in medical aesthetics and helping to standardize industry operations. In the future, the research scope will be expanded, and the diagnosis and treatment system will be optimized to improve the quality of medical aesthetics services.

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Telemedicine and Alopecia Areata: Bridging Gaps in Diagnosis and Treatment

Objectives: Objectives: 1. To define teledermatology and its role in modern dermatological care.

2. To explore how teledermatology can assist in diagnosing and managing alopecia areata.

3. To examine the advantages and limitations of teledermatology in alopecia areata treatment.

4. To discuss the technology and tools used in teledermatology for alopecia areata.

5. To identify best practices and future potential for teledermatology in hair loss disorders

Introduction: Introduction: Teledermatology has become an essential tool in dermatological care, particularly during and after the pandemic. With advancements in digital health, dermatologists can now manage various skin and hair disorders remotely. Alopecia areata, an autoimmune condition characterized by sudden hair loss, is one such condition that benefits from virtual consultation and follow-up through teledermatology.

Materials / method: Materials / method: Teledermatology utilizes synchronous (real-time video consultations) and asynchronous (store-and-forward) methods to evaluate skin and hair conditions. Technologies such as high-resolution images, teletrichoscopy (remote scalp examination), and specialized mobile apps play a key role in diagnosing and monitoring alopecia areata. These tools help dermatologists assess scalp conditions, identify hair loss patterns, and adjust treatments based on patient feedback and clinical images.

Results: Results: In cases of alopecia areata, teledermatology has proven effective in providing early diagnosis and timely interventions. Patients experience improved access to specialized care, reduced travel, and consistent follow-ups, all contributing to enhanced patient outcomes. Furthermore, patient satisfaction with teledermatology is high, with mConclusion: Teledermatology offers a promising, cost-effective solution for managing alopecia areata. While challenges remain, such as the need for better integration of tools and standardization of guidelines, the potential to improve patient care and

Conclusion: Conclusion: Teledermatology offers a promising, cost-effective solution for managing alopecia areata. While challenges remain, such as the need for better integration of tools and standardization of guidelines, the potential to improve patient care and expand access to dermatological expertise is undeniable. Future developments in telemedicine may further revolutionize how alopecia areata is diagnosed and treated.

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The Regenerative Aesthetic effects of PDLLA-PRF biostimulator Filler

Objectives: - Understand the advantages of combining PRF with PDLLA as a novel biostimulator filler.
- Apply a cost-effective procedure with natural effect results in our daily practice for our patients.
- Discuss challenges and future directions in Regenerative Aesthetics, especially injectables.

Introduction: Patients are seeking safer and cost-effective options for skin rejuvenation and facial volume restoration, and we need a protocol that blends multiple products in one treatment.
By combining Platelet Rich Fibrin (PRF) with Poly D, L-Lactic Acid (PDLLA), we harness the benefits of each ingredient in a single session. The PRF delivers potent regenerative effects through its rich supply of growth factors, while PDLLA serves as a collagen biostimulator and long-lasting filler.
Our protocol achieves Regenerative and Aesthetic effects while prioritizing safety and effectiveness.

Materials / method: We selected 5 women aged between 33 and 45 years, looking for a full-face contouring with natural shape and long-lasting effects. For each patient we used two PRF Tube (10ml) to make 8-9 ml of PRF liquid with single centrifugation at 2000 rpm (500 G) for 4 minutes, we mixed the iPRF with one vial of PDLLA biostimulator filler (using 2 luer lock 10 ml syringes and one stopcock medical connector), finally, we added 1 ml of lidocaine to have a total of 10 ml. We injected our patients with a 22G 50mm microcannulas into the subcutaneous layer to minimise the complications and discomfort.

Results: Right after the procedure, we can notice the filling effect of our Biostimulator filler. After 2 weeks, the skin tone, texture, elasticity, and hydration are improved, and pigmentation is reduced in all treated areas on the face. Our patients were satisfied with their results three months after the procedure, especially since it was done in one session. We can get better outcomes as the collagen production increases with time. No adverse events were noticed except swelling and one case of bruising.

Conclusion: The combination of injectable PRF and PDLLA represents a promising, cost-effective procedure as a biostimulator filler with potentially superior results and higher patient satisfaction. This "Regenerative Aesthetics" approach not only addresses patients' aesthetic concerns but also promotes natural tissue rejuvenation and collagen production. However, more research and studies are essential to translate this potential into a safe and effective clinical product.

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Autologous Tissue-specific Exosomes for Hair Regrowth Using Autologous Micrografting Technology - Efficacy and Safety

Objectives: This study evaluates the efficacy and safety of Autologous & Tissue-specific Exosomes using Autologous Micrografting Technology (AMT) in promoting hair regrowth in Androgenetic Alopecia.

Introduction: Hair loss resulting from androgenetic alopecia (AGA) benefits from advanced regenerative approaches that bridge medical and surgical modalities to optimize hair regrowth by stimulating follicular regeneration and enhancing scalp health. The autologous and tissue-specific exosomes obtained by AMT, has emerged as a promising strategy that leverages the body's intrinsic regenerative capacity.
AMT technology enables the precise obtaining of patient-specific progenitor cells, exosomes, growth factors and extracellular matrix components, facilitating targeted tissue-specific paracrine communication.

Materials / method: A systematic review was carried out following PRISMA guidelines, covering studies from 2019 to 2025 that evaluated the use of AMT for hair regrowth in AGA. Databases searched included PubMed, Scopus, and Embase, using keywords like “autologous micrografts,” “exosomes,” and “hair loss.” Studies involved male and female patients with early to moderate AGA. Treatments used scalp tissue processed through approved and registered medical devices to produce a biological suspension without enzymes or lab culture.

Results: AMT-derived exosomes showed strong efficacy in treating AGA, with 18–29% hair density gains and up to 24% thicker shafts in 6–12 months. Anagen/telogen ratios improved, and 77.8% of men, 81.2% of women reported visible results after one session. A 12.3 hairs/cm² increase was seen in females at 3 months. AMT was safe with mild erythema resolving quicly. No serious side effects were reported, and >90% of patients were satisfied. Contraindicated in late-stage AGA and inflamed scalps.

Conclusion: AMT containing tissue-specific and non manipulated exosomes represents a safe and an effective alternative for hair restoration in males (MPHL) and females (FPHL). AMT is a personalized approach using patient own regenerative potential to regulate the normal hair follicle function and improve hair density.

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Время	Спикеры	Заголовок сессии	Абстракт	Номер
10:30	Доктор Quan NGUYEN	Innovative Skin Aging Solutions: The Synergistic Effects of PRP and PRF with BAP Injection Technique	Посмотреть	146386
10:42	Доктор Anna BAIRAMOVA	Facial Gold Reinforcement: 28 Years of Experience in the Use of Gold Threads	Посмотреть	146387
10:54	Доктор Adham CHAKHACHIRO	Risk Factor Analysis for Vascular Occlusions after Dermal Filler Injections: A systematic review and meta-analysis	Посмотреть	146388
11:06	Доктор Zin Mar AUNG	A Structured Hair Filler Protocol for Optimal Hair Restoration Outcomes	Посмотреть	146389
11:18	Доктор Amalia TSIATOURA	Neck Rejuvenation with a Combination of PDLLA, HIFU & Botulinum Toxin A.	Посмотреть	146390
11:30	Доктор Thi Thu Trang NGUYEN	Evaluation of the efficacy and safety of combination with oral tranexamic acid, cysteamin and polynucleotide injection for melasma.	Посмотреть	146392
11:42	Доктор Lishuai SHI	Current Status and Perception of Biostimulators in China: A Cross-Sectional Study on Medical Professionals and Patients	Посмотреть	146391
11:54	Доктор Elona GABUEVA	Hybrid technique - calcium hydroxyapatite + hyaluronic acid. Instead of or together? How to achieve lifting and avoid overfill syndrome	Посмотреть	146393
12:06	Доктор Nguyen HAI	Combination of Microneedling and Microbotox for Comprehensive Facial Rejuvenation: A Case Series	Посмотреть	146395
12:18	Доктор Mikhail SUTURIN	Achieving Tissue Transposition Without the Excision of Additional Skin Folds in Minimally Invasive Forehead and Facelift Procedures	Посмотреть	146396
13:30	Доктор Sharmin JAHAN	A comparative study of hair reduction utilising a DIODE laser and an Nd: YAG laser in the Asian population.	Посмотреть	146397
13:42	Доктор Jie SUN	Visual Diagnosis and Aesthetic Restoration of the Generalized "Facial Over-filling Syndrome"	Посмотреть	146398
13:54	Доктор Amera ELSAYED ABDELHALEEM BAYUMI	Telemedicine and Alopecia Areata: Bridging Gaps in Diagnosis and Treatment	Посмотреть	146399
14:06	Доктор Mohamed EL MOUTTAKI	The Regenerative Aesthetic effects of PDLLA-PRF biostimulator Filler	Посмотреть	146400
14:18	Доктор Wing Jian FOO	Autologous Tissue-specific Exosomes for Hair Regrowth Using Autologous Micrografting Technology - Efficacy and Safety	Посмотреть	146401

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