Objectives: The indications for noninvasive facial rejuvenation are steadily increasing.Skin boosters are growing, thanks to safer and more suitable Hyaluronic acid (HA), a biodegradable product, has become the "gold standard" for fillers Mesotherapy, microneedling, and chemical peels are minimally invasive techniques used to combat facial aging. Chemical peeling is one of the oldest methods of facial rejuvenation, with reported complications
Introduction: The viability of adipose derived stem cells in the nano fat sample has been used in different indications as scars, infraorbital dark halos and perioral rhytides and neck rhytides
The microtraumatization caused by the micro needle leads to an activation of the healing cascade, activation of growth factors, which activate cell proliferation in the wound, increased synthesis and deposit of collagen - elastin complex with successive transformation of collagen III to collagenI, to neoangiogenesis and thus to accelerated skin remodelling
Materials / method: Nanofat Nanoneedling was conducted on 48 patients( 4 males, 34 females) between the period of December 2016 to June 2018 using a custom made nanoneedle device. The nanoneedling procedure was repeated three intervals approximately 6 to 8 weeks apart. In some cases the nanofat sample was mixed with PRP sample to induce a synergistic effect
Results: Although no viable adipocytes were observed in the nanofat sample, Adipose- derived stem cells were still richly present in the nanofat sample giving the treatment a superior effect.
Applications showed remarkable improvements in skin quality, skin pliability, patient and observer perception starting 2 months postoperatively. No infections, granulomas, scarring or hyperpigmentation or other unwanted side effects were observed.
Conclusion: Nanofat nanoneedling might become a new concept in facial rejuvenation as an autologous skin booster. In clinical situations, nanofat seems to be suitable for skin rejuvenation purposes.
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