摘要

Objectives: 1. To outline the best practices on the integrated treatment approach of ultrasound technology and endogenous enzymes in facial contouring 2. To outline the mechanism of action of ultrasound in lipolysis 3. To outline the mechanism of action of lipase, collagenase and hyaluronidase enzymes in lipolysis 4. To outline the value of objective evaluation of results through standardise 3D photography Introduction: The optimisation of facial contours by non-surgical means often involves a multimodal approach, which in many cases, requires the reduction of lower face volume including the jowls and submental area. The concomitant use of ultrasound technology with the injections of endogenous enzymes, produced by genetic engineering, offers a well-tolerated, minimally invasive approach to refinement of the jawline. The ultrasound system is known to destabilise the integrity of the adipocyte membrane whereas the enzymes merely enhance lipolysis of the triglycerides within the adipocyte. Materials / method: Thirteen patients were treated simultaneously with Ultrasound Technology and injected with a combination of the endogenous enzymes Lipase, Collagenase and Hyaluronidase, to treat excess volume in the lower face and submental area. Each patient received two to four treatments, spaced two weeks apart. A 3D imaging system was used for standardised photography and the objective assessment of lower facial volume, in each case. Results: All patients who received the combined treatment of ultrasound and endogenous enzymes were shown objectively to have positive results in terms of volume reduction and the improvement of jawline contours. Furthermore, patient satisfaction was high. Most importantly, the combined treatment approach was not associated with any negative treatment emergent outcomes. Conclusion: The concomitant application of ultrasound energy and endogenous enzyme showed a synergistic effect in terms of volume reduction and improvement in facial contours. The combination treatment is both safe and effective.