摘要

Objectives: To assess the effectiveness of intradermal injection of exosomes for the correction of static rhytides. Introduction: Treatment of static rhytides mainly relies on the improvement of age-related loss of skin elasticity. Exosome treatment is an emerging intervention that mitigates human dermal fibroblast senescence, directly involved in the process of skin regeneration as transporter of bioactive molecules to the recipient cells. Materials / method: A 40-year-old patient with static glabellar rhytides was administrated with a single dose of exosomes intradermally under topical anesthesia on 2 points of the bilateral glabellar furrows. Results: Patient was seen with clinically appreciable improvement one month post-procedure, with decreased depth of dermal atrophy and improvement in skin elasticity. Conclusion: Exosome therapy holds much promise as a valuable intervention for biostimulation and skin rejuvenation. Its bioactive and physiologic properties deserve to be studied more extensively clinical trials.