摘要

Objectives: Alopecia is a common clinical complaint for patients and often a source of significant psychological distress. Many treatment modalities are available. Novel drug delivery approaches are needed to maximize results and minimize potential side effects Introduction: Various trials have been conducted on the management of male and female pattern hair loss, but the outcomes often seem to be limited. Adjuvant therapies are urgently needed. Materials / method: 16 patients were enrolled in this scalp trial. Participants received monotherapy with topical minoxidil twice daily to one half of the scalp, while on the other half of the scalp the treatment with twice-daily topical minoxidil was combined with five sessions of Radiofrequency (RF) microneedling at 4-week intervals. Mean hair count and hair thickness, global assessment by the investigators, subject self-assessment and adverse effects were assessed. Results: After 5 months of treatment, mean hair count and hair thickness increased significantly on the combined-therapy side. No side effects were noticed. Conclusion: Combined treatment with fractional radiofrequency microneedling, topical minoxidil and nano drug delivery particles could be an effective and safe treatment option for male pattern hair loss.