摘要

Objectives: Several clinical studies of the photodynamic treatment of actinic keratosis and actinic cheilitis demonstrated that White LED photodynamic therapy(PDT) is a valuable alternative to conventional PDT performed with red light with better tolerability (almost painless) and lack of inferior efficacy. In addition, White LED illumination seems to present practical advantages in comparison with outdoor daylight PDT because the spectrum and light dose are fixed and reproducible and it is always feasible and programmable regardless of weather and environmental problems. Materials / method: Fronville M, Creusot M, Mordon SR. Is a 4 J/cm2 PpIX-Weighted Simulated Daylight (SDL-PDT) Dose Still Efficient for Photodynamic Therapy of Actinic Keratosis? Pharmaceuticals (Basel). 2023 Oct 13;16(10):1454. Arisi M, Rossi MT, Spiazzi L, Guasco Pisani E, Venturuzzo A, Rovati C, Tomasi C, Venturini M, Calzavara-Pinton PG. A randomized split-face clinical trial of conventional vs indoor-daylight photodynamic therapy for the treatment of multiple actinic keratosis of the face and scalp and photoaging. J Dermatolog Treat. 2022 Jun;33(4):2250-2256. Results: Arisi M, Galli B, Pisani EG, La Rosa G, Licata G, Rovaris S, Tomasi C, Rossi M, Venturini M, Spiazzi L, Calzavara-Pinton P. Randomized Clinical Trial of Conventional versus Indoor Daylight Photodynamic Therapy for Treatment of Actinic Cheilitis. Dermatol Ther (Heidelb). 2022 Sep;12(9):2049-2061. Creusot M, Mordon S. Clinical evaluation of a short illumination duration (1 hour) when performing photodynamic therapy of actinic keratosis using the Dermaris light source. Photodiagnosis Photodyn Ther. 2021 Dec;36:102618 Conclusion: Maire C, Vignion-Dewalle AS, Cartier H, Mordon S. Artificial white light photodynamic therapy for actinic keratosis: a study of 38 patients in private office practice. J Eur Acad Dermatol Venereol. 2020 Apr;34(4):e165-e167.