摘要

Objectives: This study investigates the application of Poly-D,L-Lactic Acid (PDLLA) as a biostimulatory agent for skin rejuvenation in menopausal women, aiming to address age-related dermatological concerns effectively. Additionally, the study included a comparison to alternative methods like HA fillers and threads in the same patients to evaluate the relative efficacy of PDLLA. Introduction: Menopause heralds a significant shift in a woman's life, accompanied by physiological changes that prominently affect skin health. The decline in estrogen levels leads to reduced collagen production, increased skin laxity, and the appearance of wrinkles, profoundly impacting quality of life and self-perception. PDLLA, a biodegradable polymer known for its collagen-stimulating properties, has emerged as a promising solution in aesthetic medicine. Materials / method: This research delves into the mechanism of action, clinical efficacy, and safety profile of PDLLA in treating menopausal skin. A comprehensive analysis of clinical trials and patient case studies was conducted to examine the long-term benefits of PDLLA injections in enhancing dermal volume, elasticity, and overall skin texture. The study included a comparison to alternative methods such as hyaluronic acid (HA) fillers and thread lifts, applied to the same patients, to provide a direct evaluation of PDLLA's performance relative to these established treatments. Results: Our findings indicate that PDLLA significantly stimulates collagen neogenesis, leading to noticeable improvements in skin firmness, reduction in wrinkle depth, and enhanced hydration. Additionally, PDLLA injections have been shown to correct bone loss, a common issue in post-menopausal women, thereby contributing to a more youthful facial structure. Patients also reported a marked decrease in skin irritation and overall improved skin quality. In comparison to HA fillers and threads, PDLLA demonstrated superior long-term results in collagen stimulation and skin rejuvenation. Conclusion: The progressive nature of PDLLA's action offers sustained and natural-looking rejuvenation, which is particularly beneficial for the delicate and aging skin of menopausal women. Furthermore, the biocompatibility and minimal side effect profile of PDLLA make it a superior alternative to traditional dermal fillers and invasive surgical procedures. The comparative analysis with HA fillers and threads highlights PDLLA's advantages in achieving more durable and effective skin rejuvenation.