摘要

Objectives: The study aimed to investigate the efficacy and safety of using hyaluronic acid filler for facial lifting. Introduction: Facial aging in middle-aged individuals is influenced by intrinsic and extrinsic factors. In the anatomical overview for aging, three main structures are affected, including fat deflation, bone resorption, and ligament attenuation. Aging changes in ligaments contributed to facial sagging along with volume loss. To support sagging in facial layers and gravitational related, targeting the facial ligaments with the right characteristic of hyaluronic acid filler in a minimal amount offers more refined and maximal lifting support. Materials / method: This clinical trial study recruited seventeen female participants aged 30-55 with mild to moderate skin laxity. A total of 3.3 ml high G prime hyaluronic acid filler was delivered by 27G sharp needle; we have developed seven injection points to target facial retaining ligaments; by injecting the zygomatic cutaneous ligaments, mandible angle, mandibular septum, mandibular cutaneous ligament, pyriform fossa, platysma-auricular fascia and residual filler were used to correct the chin. Clinical outcomes were evaluated by MEAN volume difference by Vectra. Results: The clinical evaluation of patients' satisfaction scores showed a great improvement from the immediate post-injection. Our data demonstrated a significant result in the lifting effect, with an increase in volume change in the mandible and chin area from the baseline. The pyriform fossa also showed improvement, and the results lasted until six months. Notably, with the lifting in the zygomatic region, the results showed more refining, contouring, and lifting in the mid-cheek area. Some adverse effects were observed during the study such as edema, erythema, wheal, bruising, and mucocele. Conclusion: Our clinical study has shown that our seven-point lifting techniques provided a predictable outcome of facial lifting for middle-aged female patients. These findings are significant as they underscore the key factors for achieving maximal facial lifting effects, which consist of the right patient selection, the right techniques, corrective injection plan, and using hyaluronic acid filler with high G prime and high lifting capacity. This study's findings have the potential to significantly impact the field of facial rejuvenation.