摘要

Objectives: 1. Create a protocol that combines fractional radiofrequency with microneedles with polynucleotide injection for the treatment of skin quality and facial sagging 2. To study the effectiveness of combining fractional radiofrequency with microneedles with polynucleotide injection 3. To study the safety of combining microneedle fractional radiofrequency with polynucleotide injection Introduction: Regenerative medicine seeks to activate the repair pathways themselves to "rejuvenate" tissues. This trend has reached aesthetic medicine, combining different non-invasive techniques that avoid the use of fillers and semi-permanent products. Fractional radiofrequency with microneedles uses energy producing a mechanical and coagulation effect. This device together with the repairing and stimulating power of the polynucleotide can be a safe combination for the treatment of sagging and skin quality, stimulating collagen synthesis and reorganizing it. Materials / method: 5 patients, 4 women and 1 man (32-56 years old), were treated with fractional radiofrequency with microneedles (800-1500mJ/pulse, monopolar, bipolar mode, 1-2MHz, 500-1000 pulse per patient).All patients were treated with 2ml of polynucleotides (20mg/ml). 3 sessions, 1 per month, were done. The patient was followed up (48h and 1 months after each sessions) by photography, Global Aesthetic Improvement Scale (patient and doctor), standardized scales for glabella, dark circles, sagging and skin quality. Pain was recorded using a visual scale. All adverse events were recorded. Results: All patients and doctor reported an improvement in sagging and skin quality after first session. An improvement was observed in all scales, with a greater improvement observed after 2 months. No serious adverse events were recorded. Erythema and edema disappeared within 48 hours after treatment. One patient had a mild flare-up of folliculitis that resolved without treatment. The bruises or needle marks disappeared in the first 7 days. No infections or hyperpigmentations were observed, not even in patients suffering from melasma. Conclusion: The combination of fractional radiofrequency with microneedles and polynucleotide infiltration is an effective and safe treatment in improving sagging and skin quality, without the need to use fillers or semi-permanent products. A comparative study with a larger number of patients is needed to prove the superiority of this type of combination with respect to separate treatments and with respect to other semi-permanent products.